| Literature DB >> 9136851 |
B Macfarlane1, S Davies, K Mannan, R Sarsam, D Pariente, J Dooley.
Abstract
Clozapine-induced hepatotoxicity is not well known and is usually of no clinical significance. This report describes fatal acute fulminant liver failure caused by clozapine in a 39-year-old man with chronic paranoid schizophrenia. The hepatotoxicity of clozapine is reviewed. Asymptomatic elevation of transaminase levels is observed most commonly, affecting between 30% and 50% of patients. Icteric hepatitis is uncommon, noted in 84 of 136,000 patients (0.06%). Fatal acute fulminant hepatitis has been documented in 2 patients (0.001%). The mechanism of clozapine hepatotoxicity is unknown. Although serious toxicity is rare, prescribers of clozapine should be aware of the hepatotoxic potential.Entities:
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Year: 1997 PMID： 9136851 DOI： 10.1016/s0016-5085(97)70054-4
Source DB: PubMed Journal: Gastroenterology ISSN： 0016-5085 Impact factor: 22.682