Literature DB >> 913428

Investigations into the use of 77Br labelled 5alpha-dihydrotestosterone for scanning the prostate.

R Ghanadian, S L Waters, G D Chisholm.   

Abstract

The potential use of a potent androgen labelled with a gamma emitting radionuclide for scanning the prostate was investigated. 2alphabromo 5alpha-dihydrotestosterone was synthesized and subsequently labelled with 77Br. The distribution of this compound was studied in rat and human tissues. The maximum concentration of radioactivity in the rat prostate at 1-4 h following the injection was found to be between 0.5-0.8% of the injected dose per gram of the tissue. In the human however, that value was 0.002-0.003%. Considering the overall results it was concluded that this compound is not appropriate for scanning the prostate.

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Year:  1977        PMID： 913428     DOI： 10.1007/bf00257273

Source DB:  PubMed          Journal:  Eur J Nucl Med        ISSN： 0340-6997


  10 in total

1.  Studies with radioactive iodine labelled oestrogens as prostate scanning agents.

Authors:  R Ghanadian; S L Waters; M L Thakur; G D Chisholm
Journal:  Int J Appl Radiat Isot       Date:  1975 Jun-Jul

2.  The inhibitive effects of steroid analogues in the binding of tritiated 5alpha-dihydrotestosterone to receptor proteins from rat prostate tissue.

Authors:  R W Skinner; R V Pozderac; R E Counsell; P A Weinhold
Journal:  Steroids       Date:  1975-02       Impact factor: 2.668

3.  Concepts and limitations in the application of radiolabeled antiandrogens, estrogens, or androgens as isotopic scanning agents for the prostate.

Authors:  B Berger; D S Coffey; W W Scott
Journal:  Invest Urol       Date:  1975-07

4.  Radiozinc uptake and scintiscanning in prostatic disease.

Authors:  G D Chisholm; M D Short; R Ghanadian; C U McRae; H I Glass
Journal:  J Nucl Med       Date:  1974-09       Impact factor: 10.057

5.  Isotope scanning of the prostate.

Authors:  Z Szendröi; L Kocsár; Z Karika; S Eckhardt
Journal:  Lancet       Date:  1973-06-02       Impact factor: 79.321

6.  Inhibition of the 3-ketosteroid 5 - 4 -isomerase of Pseudomonas testosteroni by some bromo-3-ketosteroid derivatives.

Authors:  J B Jones; S Ship
Journal:  Biochim Biophys Acta       Date:  1972-03-08

7.  65-Zn and 69m-Zn studies in the dog, monkey, and man. Prostatic scintiscanning.

Authors:  G S Johnston; J C Wade; G P Murphy; W W Scott
Journal:  J Surg Res       Date:  1968-11       Impact factor: 2.192

8.  The distribution of 131I labeled diethylstilbestrol diphosphate in animals and men with observations on its potential use as a scanning agent of the prostate.

Authors:  M Tubis; J S Endow; W H Blahd
Journal:  Nucl Med (Stuttg)       Date:  1967-07-15

9.  The use of 123I labelled oestradiol in detecting the human prostate using a gamma camera.

Authors:  R Ghanadian; S L Waters; G Williams; G D Chisholm
Journal:  Eur J Nucl Med       Date:  1976-08-12

10.  Intracellular localisation of 5alpha-dihydrotestosterone in human benign prostatic hypertrophy.

Authors:  R Ghanadian; G D Chisholm; K Fotherby
Journal:  Clin Chim Acta       Date:  1976-12       Impact factor: 3.786
  10 in total
  3 in total

1.  The distribution of 75Se-adenosyl selenomethionine in the rat with observations on its potential as a prostate scanning agent.

Authors:  M N Eakins
Journal:  Eur J Nucl Med       Date:  1979-04-01

2.  The uptake of radioiodinated 5 alpha-dihydrotestosterone by the prostate of intact and castrated rats.

Authors:  M Tarle; R Padovan; S Spaventi
Journal:  Eur J Nucl Med       Date:  1981-02

Review 3.  PET Imaging Agents (FES, FFNP, and FDHT) for Estrogen, Androgen, and Progesterone Receptors to Improve Management of Breast and Prostate Cancers by Functional Imaging.

Authors:  John A Katzenellenbogen
Journal:  Cancers (Basel)       Date:  2020-07-23       Impact factor: 6.639
  3 in total

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