| Literature DB >> 9133642 |
B Lorenz1, J Münkner, M P Oliveira, A Kuusksalu, J M Leitão, W E Müller, H C Schröder.
Abstract
Age-dependent studies show that the amount of inorganic polyphosphate in rat brain strongly increases after birth. Maximal levels were found in 12-months old animals. Thereafter, the concentration of total polyphosphate decreases to about 50%. This decrease in the concentration of total polyphosphate is due to a decrease in the amount of insoluble, long-chain polyphosphates. The amount of soluble, long-chain polyphosphates does not change significantly in the course of ageing. In rat embryos and newborns, mainly soluble polyphosphates could be detected. In rat liver, the age-dependent changes are less pronounced. The changes in polyphosphate level are accompanied by changes in exopolyphosphatase activity, which degrades the polymers to orthophosphate; highest enzyme activities were found when the polyphosphate level was low. Induction of apoptosis in the human leukemic cell line HL-60 by actinomycin D results in degradation of long polyphosphate chains. The total polyphosphate content does not change significantly in apoptotic cells.Entities:
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Year: 1997 PMID： 9133642 DOI： 10.1016/s0304-4165(96)00121-3
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002