Literature DB >> 9133586

Cloning and characterization of human cDNAs encoding a protein with high homology to rat intestinal development protein OCI-5.

H Lage1, M Dietel.   

Abstract

We constructed a lambda complementary DNA expression library from the mitoxantrone-resistant human gastric carcinoma cell line EPG85-257RNOV. The library was screened by differential hybridization (resistant cell line against non-resistant cell variant). By this procedure we found five independent cDNA clones representing one single gene that has much higher expression in the mitoxantrone-resistant cell line EPG85-257RNOV than in the non-resistant variant EPG85-257P. One of the cDNA clones (MXR7) contains a complete open reading frame (ORF) encoding a 580-amino acid polypeptide. Amino acid and nucleotide sequence analysis revealed that this gene codes the human variant of a rat intestinal development protein OCI-5.

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Year:  1997        PMID： 9133586     DOI： 10.1016/s0378-1119(96)00689-0

Source DB:  PubMed          Journal:  Gene        ISSN： 0378-1119            Impact factor:   3.688


  6 in total

1.  Cloning and expression of MXR7 gene in human HCC tissue.

Authors:  Xue-Ping Zhou; Hong-Yang Wang; Guang-Shun Yang; Zheng-Jun Chen; Bao-An Li; Meng-Chao Wu
Journal:  World J Gastroenterol       Date:  2000-02       Impact factor: 5.742

2.  Meta-analysis and systematic review of prognostic significance of Glypican-3 in patients with hepatitis B-related hepatocellular carcinoma.

Authors:  Bita Moudi; Zahra Heidari; Hamidreza Mahmoudzadeh-Sagheb
Journal:  Virusdisease       Date:  2019-03-28

3.  Taxol-resistance-associated gene-3 (TRAG-3/CSAG2) expression is predictive for clinical outcome in ovarian carcinoma patients.

Authors:  Verena Materna; Paweł Surowiak; Irina Kaplenko; Merek Spaczyński; Zhenfeng Duan; Maciej Zabel; Manfred Dietel; Hermann Lage
Journal:  Virchows Arch       Date:  2007-02       Impact factor: 4.064

Review 4.  Glypican-3 and alphafetoprotein as diagnostic tests for hepatocellular carcinoma.

Authors:  Jorge Filmus; Mariana Capurro
Journal:  Mol Diagn       Date:  2004

Review 5.  Immunotherapeutic Targeting of GPC3 in Pediatric Solid Embryonal Tumors.

Authors:  Michael V Ortiz; Stephen S Roberts; Julia Glade Bender; Neerav Shukla; Leonard H Wexler
Journal:  Front Oncol       Date:  2019-02-26       Impact factor: 6.244

Review 6.  Overexpression of glypican-3 is a predictor of poor prognosis in hepatocellular carcinoma: An updated meta-analysis.

Authors:  Jian Zhang; Manka Zhang; Huimin Ma; Xincheng Song; Lingling He; Xiaohui Ye; Xin Li
Journal:  Medicine (Baltimore)       Date:  2018-06       Impact factor: 1.889
  6 in total

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