Literature DB >> 9133445

Smad5 induces ventral fates in Xenopus embryo.

A Suzuki1, C Chang, J M Yingling, X F Wang, A Hemmati-Brivanlou.   

Abstract

The Smad proteins have been implicated in the intracellular signaling of transforming growth factor-beta (TGF-beta) ligands. Here we describe the function of Smad5 in early Xenopus development. Misexpression of Smad5 in the embryo causes ventralization and induces ventral mesoderm. Moreover, Smad5 induces epidermis in dissociated ectoderm cells which would otherwise form neural tissue. Both of these activities require Smad4 (DPC4) activity. We propose that Smad5 acts downstream of the BMP4 signaling pathway in Xenopus embryos and directs the formation of ventral mesoderm and epidermis.

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Year:  1997        PMID： 9133445     DOI： 10.1006/dbio.1997.8548

Source DB:  PubMed          Journal:  Dev Biol        ISSN： 0012-1606            Impact factor:   3.582


  26 in total

Review 1.  Specificity in transforming growth factor-beta signaling pathways.

Authors:  C J Ring; K W Cho
Journal:  Am J Hum Genet       Date:  1999-03       Impact factor: 11.025

2.  Rap2 is required for Wnt/beta-catenin signaling pathway in Xenopus early development.

Authors:  Sun-Cheol Choi; Jin-Kwan Han
Journal:  EMBO J       Date:  2005-02-10       Impact factor: 11.598

3.  STAT5 acts as a repressor to regulate early embryonic erythropoiesis.

Authors:  Matthew Schmerer; Ingrid Torregroza; Aude Pascal; Muriel Umbhauer; Todd Evans
Journal:  Blood       Date:  2006-07-11       Impact factor: 22.113

4.  Determinants of specificity in TGF-beta signal transduction.

Authors:  Y G Chen; A Hata; R S Lo; D Wotton; Y Shi; N Pavletich; J Massagué
Journal:  Genes Dev       Date:  1998-07-15       Impact factor: 11.361

5.  Myo/Nog cell regulation of bone morphogenetic protein signaling in the blastocyst is essential for normal morphogenesis and striated muscle lineage specification.

Authors:  Jacquelyn Gerhart; Victoria L Scheinfeld; Tara Milito; Jessica Pfautz; Christine Neely; Dakota Fisher-Vance; Kelly Sutter; Mitchell Crawford; Karen Knudsen; Mindy George-Weinstein
Journal:  Dev Biol       Date:  2011-08-18       Impact factor: 3.582

6.  Tumor suppressor Smad4 is a transforming growth factor beta-inducible DNA binding protein.

Authors:  J M Yingling; M B Datto; C Wong; J P Frederick; N T Liberati; X F Wang
Journal:  Mol Cell Biol       Date:  1997-12       Impact factor: 4.272

7.  Smad8 mediates the signaling of the ALK-2 [corrected] receptor serine kinase.

Authors:  Y Chen; A Bhushan; W Vale
Journal:  Proc Natl Acad Sci U S A       Date:  1997-11-25       Impact factor: 11.205

8.  Role of TAK1 and TAB1 in BMP signaling in early Xenopus development.

Authors:  H Shibuya; H Iwata; N Masuyama; Y Gotoh; K Yamaguchi; K Irie; K Matsumoto; E Nishida; N Ueno
Journal:  EMBO J       Date:  1998-02-16       Impact factor: 11.598

9.  Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene.

Authors:  S Dennler; S Itoh; D Vivien; P ten Dijke; S Huet; J M Gauthier
Journal:  EMBO J       Date:  1998-06-01       Impact factor: 11.598

10.  Nuclear accumulation of S-adenosylhomocysteine hydrolase in transcriptionally active cells during development of Xenopus laevis.

Authors:  N Radomski; C Kaufmann; C Dreyer
Journal:  Mol Biol Cell       Date:  1999-12       Impact factor: 4.138
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