Literature DB >> 9131898

Nature and healing of tibial shaft fractures in alcohol abusers.

F Nyquist1, M Berglund, B E Nilsson, K J Obrant.   

Abstract

Alcohol abuse is associated with an increased risk of osteopenia and fractures. Previous histomorphometric studies on iliac crest bone have found decreased bone formation and increased bone resorption in alcohol abusers but it has not been established whether alcohol abuse has any effect on the anatomical location or the healing time of tibial shaft fractures. We studied, retrospectively, 199 adult male patients hospitalized for isolated tibial shaft fracture in the city of Malmö, Sweden, between 1980 and 1990. Forty-nine of the patients had earlier been registered at the Department of Alcohol Diseases and were judged to be problem drinkers. Abusers sustained their tibial shaft fractures more often by falling at ground level (P < 0.0001) or from a higher level (P = 0.009) and the fractures were more often oblique than transverse (P = 0.002) as compared with non-abusers. Healing time was impaired in abusers who had sustained a transverse fracture (P = 0.035), but no difference was observed in healing time in those with a oblique fracture. We found no difference between the abusers and the non-abusers regarding duration of hospital stay, fracture location, amount of displacement, occurrence of open fractures or the rate of complications.

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Year:  1997        PMID: 9131898     DOI: 10.1093/oxfordjournals.alcalc.a008240

Source DB:  PubMed          Journal:  Alcohol Alcohol        ISSN: 0735-0414            Impact factor:   2.826


  17 in total

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2.  Alcohol inhibits osteopontin-dependent transforming growth factor-β1 expression in human mesenchymal stem cells.

Authors:  Joseph Driver; Cynthia E Weber; John J Callaci; Anai N Kothari; Matthew A Zapf; Philip M Roper; Dariusz Borys; Carrie A Franzen; Gopal N Gupta; Philip Y Wai; Jiwang Zhang; Mitchell F Denning; Paul C Kuo; Zhiyong Mi
Journal:  J Biol Chem       Date:  2015-02-24       Impact factor: 5.157

3.  Prognostic factors for predicting outcomes after intramedullary nailing of the tibia.

Authors:  Emil H Schemitsch; Mohit Bhandari; Gordon Guyatt; David W Sanders; Marc Swiontkowski; Paul Tornetta; Stephen D Walter; Rad Zdero; J C Goslings; David Teague; Kyle Jeray; Michael D McKee
Journal:  J Bone Joint Surg Am       Date:  2012-10-03       Impact factor: 5.284

4.  The Gustilo-Anderson classification system as predictor of nonunion and infection in open tibia fractures.

Authors:  R V Thakore; E L Francois; S K Nwosu; B Attum; P S Whiting; M A Siuta; M A Benvenuti; A K Smith; M S Shen; I Mousavi; W T Obremskey; M K Sethi
Journal:  Eur J Trauma Emerg Surg       Date:  2016-09-22       Impact factor: 3.693

5.  Alcohol-related deficient fracture healing is associated with activation of FoxO transcription factors in mice.

Authors:  Philip M Roper; Pegah Abbasnia; Aleksandra Vuchkovska; Roman M Natoli; John J Callaci
Journal:  J Orthop Res       Date:  2016-07-29       Impact factor: 3.494

6.  N-Acetyl Cysteine Treatment Restores Early Phase Fracture Healing in Ethanol-Fed Rats.

Authors:  Michael J Duryee; Anand Dusad; Carlos D Hunter; Kusum K Kharbanda; Joseph D Bruenjes; Karen C Easterling; Justin C Siebler; Geoffrey M Thiele; Dennis A Chakkalakal
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Review 7.  MicroRNAs: master regulators of ethanol abuse and toxicity?

Authors:  Rajesh C Miranda; Andrzej Z Pietrzykowski; Yueming Tang; Pratheesh Sathyan; Dayne Mayfield; Ali Keshavarzian; Wayne Sampson; Dale Hereld
Journal:  Alcohol Clin Exp Res       Date:  2010-01-26       Impact factor: 3.455

8.  Impact of Alcohol on Bone Health, Homeostasis and Fracture repair.

Authors:  Jonathan M Eby; Farah Sharieh; John J Callaci
Journal:  Curr Pathobiol Rep       Date:  2020-07-28

9.  Alcoholism as a predictor for pseudarthrosis in primary spine fusion: An analysis of risk factors and 30-day outcomes for 52,402 patients from 2005 to 2013.

Authors:  Peter G Passias; Cole Bortz; Haddy Alas; Frank A Segreto; Samantha R Horn; Yael U Ihejirika; Dennis Vasquez-Montes; Katherine E Pierce; Avery E Brown; Kartik Shenoy; Edward M DelSole; Bradley Johnson; Cheongeun Oh; Peter L Zhou; Chloe Deflorimonte; Ekhamjeet S Dhillon; Pawel P Jankowski; Bassel G Diebo; Virginie Lafage; Renaud Lafage; Shaleen N Vira; John A Bendo; Jeffrey A Goldstein; Frank J Schwab; Michael C Gerling
Journal:  J Orthop       Date:  2018-12-20

10.  Ethanol Inhibits Mesenchymal Stem Cell Osteochondral Lineage Differentiation Due in Part to an Activation of Forkhead Box Protein O-Specific Signaling.

Authors:  Farah Sharieh; Jonathan M Eby; Philip M Roper; John J Callaci
Journal:  Alcohol Clin Exp Res       Date:  2020-05-18       Impact factor: 3.455

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