Literature DB >> 9131721

The glycine receptor.

S Rajendra1, J W Lynch, P R Schofield.   

Abstract

The inhibitory glycine receptor (GlyR) is a member of the ligand-gated ion channel receptor superfamily. The GlyR comprises a pentameric complex that forms a chloride-selective transmembrane channel, which is predominantly expressed in the spinal cord and brain stem. We review the pharmacological and physiological properties of the GlyR and relate this information to more recent insights that have been obtained through the cloning and recombinant expression of the GlyR subunits. We also discuss insights into our understanding of GlyR structure and function that have been obtained by the genetic characterisation of various heritable disorders of glycinergic neurotransmission.

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Year:  1997        PMID： 9131721     DOI： 10.1016/s0163-7258(96)00163-5

Source DB:  PubMed          Journal:  Pharmacol Ther        ISSN： 0163-7258            Impact factor:   12.310


  60 in total

Review 1.  Cell receptors and cell signalling.

Authors:  I J Uings; S N Farrow
Journal:  Mol Pathol       Date:  2000-12

2.  Kinetic determinants of agonist action at the recombinant human glycine receptor.

Authors:  Trevor M Lewis; Peter R Schofield; Annette M L McClellan
Journal:  J Physiol       Date:  2003-04-04       Impact factor: 5.182

3.  Charge and geometry of residues in the loop 2 β hairpin differentially affect agonist and ethanol sensitivity in glycine receptors.

Authors:  Daya I Perkins; James R Trudell; Liana Asatryan; Daryl L Davies; Ronald L Alkana
Journal:  J Pharmacol Exp Ther       Date:  2012-02-22       Impact factor: 4.030

4.  Crystal structure of human glycine receptor-α3 bound to antagonist strychnine.

Authors:  Xin Huang; Hao Chen; Klaus Michelsen; Stephen Schneider; Paul L Shaffer
Journal:  Nature       Date:  2015-09-28       Impact factor: 49.962

5.  Glycine receptors in a population of adult mammalian cones.

Authors:  E Balse; L-H Tessier; V Forster; M J Roux; J A Sahel; S Picaud
Journal:  J Physiol       Date:  2006-01-05       Impact factor: 5.182

Review 6.  Tandem couture: Cys-loop receptor concatamer insights and caveats.

Authors:  Spencer S Ericksen; Andrew J Boileau
Journal:  Mol Neurobiol       Date:  2007-02       Impact factor: 5.590

7.  Quantitative analysis of neurons with Kv3 potassium channel subunits, Kv3.1b and Kv3.2, in macaque primary visual cortex.

Authors:  Christine M Constantinople; Anita A Disney; Jonathan Maffie; Bernardo Rudy; Michael J Hawken
Journal:  J Comp Neurol       Date:  2009-10-01       Impact factor: 3.215

8.  Pharmacological characterization of the homomeric and heteromeric UNC-49 GABA receptors in C. elegans.

Authors:  Bruce A Bamber; Roy E Twyman; Erik M Jorgensen
Journal:  Br J Pharmacol       Date:  2003-03       Impact factor: 8.739

9.  Acute high-dose glycine attenuates mismatch negativity (MMN) in healthy human controls.

Authors:  Sumie Leung; Rodney J Croft; Barry V O'Neill; Pradeep J Nathan
Journal:  Psychopharmacology (Berl)       Date:  2007-10-20       Impact factor: 4.530

10.  Localization of glycine receptors in the human forebrain, brainstem, and cervical spinal cord: an immunohistochemical review.

Authors:  Kristin Baer; Henry J Waldvogel; Richard L M Faull; Mark I Rees
Journal:  Front Mol Neurosci       Date:  2009-11-04       Impact factor: 5.639
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