Literature DB >> 9129673

PrP genotypes and experimental scrapie in orally inoculated Suffolk sheep in the United States.

K I O'Rourke1, G R Holyoak, W W Clark, J R Mickelson, S Wang, R P Melco, T E Besser, W C Foote.   

Abstract

One-hundred and three Unites States Suffolk sheep were inoculated orally with a scrapie agent preparation and monitored for clinical disease and histopathological lesions characteristic of scrapie. A retrospective study of the polymorphisms at codon 171 of the prion protein (PrP) gene was performed on these sheep. All 63 sheep that developed scrapie during the observation period were homozygous for the glutamine 171 (171-QQ) PrP allele. Twelve 171-QQ sheep failed to develop disease. All 5 sheep homozygous for arginine (171-RR) and all 23 heterozygous (171-QR) sheep remained free of scrapie.

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Year:  1997        PMID： 9129673     DOI： 10.1099/0022-1317-78-4-975

Source DB:  PubMed          Journal:  J Gen Virol        ISSN： 0022-1317            Impact factor:   3.891


  25 in total

1.  Pregnancy status and fetal prion genetics determine PrPSc accumulation in placentomes of scrapie-infected sheep.

Authors:  Wenbin Tuo; Katherine I O'Rourke; Dongyue Zhuang; William P Cheevers; Terry R Spraker; Donald P Knowles
Journal:  Proc Natl Acad Sci U S A       Date:  2002-04-16       Impact factor: 11.205

2.  Federal disease control--scrapie.

Authors:  Penelope Greenwood
Journal:  Can Vet J       Date:  2002-08       Impact factor: 1.008

3.  Scrapie resistance in ARQ sheep.

Authors:  W W Laegreid; M L Clawson; M P Heaton; B T Green; K I O'Rourke; D P Knowles
Journal:  J Virol       Date:  2008-07-16       Impact factor: 5.103

Review 4.  Scrapie.

Authors:  N Hunter
Journal:  Mol Biotechnol       Date:  1998-06       Impact factor: 2.695

5.  Evidence for protein X binding to a discontinuous epitope on the cellular prion protein during scrapie prion propagation.

Authors:  K Kaneko; L Zulianello; M Scott; C M Cooper; A C Wallace; T L James; F E Cohen; S B Prusiner
Journal:  Proc Natl Acad Sci U S A       Date:  1997-09-16       Impact factor: 11.205

6.  Solution structure of a 142-residue recombinant prion protein corresponding to the infectious fragment of the scrapie isoform.

Authors:  T L James; H Liu; N B Ulyanov; S Farr-Jones; H Zhang; D G Donne; K Kaneko; D Groth; I Mehlhorn; S B Prusiner; F E Cohen
Journal:  Proc Natl Acad Sci U S A       Date:  1997-09-16       Impact factor: 11.205

7.  Effect of domestication on the spread of the [PIN+] prion in Saccharomyces cerevisiae.

Authors:  Amy C Kelly; Ben Busby; Reed B Wickner
Journal:  Genetics       Date:  2014-05-08       Impact factor: 4.562

8.  Active surveillance for scrapie by third eyelid biopsy and genetic susceptibility testing of flocks of sheep in Wyoming.

Authors:  Katherine I O'Rourke; John V Duncan; James R Logan; Anne K Anderson; Dianne K Norden; Elizabeth S Williams; Bret A Combs; Robert H Stobart; Gary E Moss; Diane L Sutton
Journal:  Clin Diagn Lab Immunol       Date:  2002-09

9.  Prion gene sequence variation within diverse groups of U.S. sheep, beef cattle, and deer.

Authors:  Michael P Heaton; Kreg A Leymaster; Brad A Freking; Deedra A Hawk; Timothy P L Smith; John W Keele; Warren M Snelling; James M Fox; Carol G Chitko-McKown; William W Laegreid
Journal:  Mamm Genome       Date:  2003-11       Impact factor: 2.957

10.  Transmissibility of atypical scrapie in ovine transgenic mice: major effects of host prion protein expression and donor prion genotype.

Authors:  Jean-Noël Arsac; Dominique Bétemps; Eric Morignat; Cécile Féraudet; Anna Bencsik; Denise Aubert; Jacques Grassi; Thierry Baron
Journal:  PLoS One       Date:  2009-10-06       Impact factor: 3.240
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