Literature DB >> 9128855

A rapid and reversible change in dopamine transporters induced by methamphetamine.

A E Fleckenstein1, R R Metzger, J W Gibb, G R Hanson.   

Abstract

Because high doses of methamphetamine promote free radical formation, and striatal dopamine transporters are rapidly inactivated by oxidative events, we determined the effect of a single high dose of methamphetamine on dopamine transporter activity in striatal synaptosomes. One hour after methamphetamine administration, dopamine uptake decreased by 48%. This dramatic decline was totally reversed by 24 h after treatment. These findings suggest that methamphetamine reversibly decreases dopamine transporter activity by oxidative mechanisms.

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Year:  1997        PMID： 9128855     DOI： 10.1016/s0014-2999(97)00148-9

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  17 in total

1.  Cortical ionotropic glutamate receptor antagonism protects against methamphetamine-induced striatal neurotoxicity.

Authors:  N B Gross; P C Duncker; J F Marshall
Journal:  Neuroscience       Date:  2011-09-16       Impact factor: 3.590

2.  Methamphetamine, 3,4-methylenedioxymethamphetamine (MDMA) and 3,4-methylenedioxypyrovalerone (MDPV) induce differential cytotoxic effects in bovine brain microvessel endothelial cells.

Authors:  Hector Rosas-Hernandez; Elvis Cuevas; Susan M Lantz; Kenner C Rice; Brenda M Gannon; William E Fantegrossi; Carmen Gonzalez; Merle G Paule; Syed F Ali
Journal:  Neurosci Lett       Date:  2016-06-16       Impact factor: 3.046

3.  Disparity in the temporal appearance of methamphetamine-induced apoptosis and depletion of dopamine terminal markers in the striatum of mice.

Authors:  Judy P Q Zhu; Wenjing Xu; Jesus A Angulo
Journal:  Brain Res       Date:  2005-07-12       Impact factor: 3.252

Review 4.  The sigma-1 receptor as a regulator of dopamine neurotransmission: A potential therapeutic target for methamphetamine addiction.

Authors:  Danielle O Sambo; Joseph J Lebowitz; Habibeh Khoshbouei
Journal:  Pharmacol Ther       Date:  2018-01-31       Impact factor: 12.310

5.  Neonatal +-methamphetamine exposure in rats alters adult locomotor responses to dopamine D1 and D2 agonists and to a glutamate NMDA receptor antagonist, but not to serotonin agonists.

Authors:  Devon L Graham; Robyn M Amos-Kroohs; Amanda A Braun; Curtis E Grace; Tori L Schaefer; Matthew R Skelton; Michael T Williams; Charles V Vorhees
Journal:  Int J Neuropsychopharmacol       Date:  2012-03-06       Impact factor: 5.176

6.  Role of dopamine D2-like receptors and their modulation by adenosine receptor stimulation in the reinstatement of methamphetamine seeking.

Authors:  Tracey A Larson; Madeline C Winkler; Jacob Stafford; Sophia C Levis; Casey E O'Neill; Ryan K Bachtell
Journal:  Psychopharmacology (Berl)       Date:  2018-11-23       Impact factor: 4.530

7.  The Role of Biogenic Amine Transporters in Trace Amine-Associated Receptor 1 Regulation of Methamphetamine-Induced Neurotoxicity.

Authors:  Nicholas B Miner; Tamara J Phillips; Aaron Janowsky
Journal:  J Pharmacol Exp Ther       Date:  2019-07-18       Impact factor: 4.030

Review 8.  Role of monoamine transporters in mediating psychostimulant effects.

Authors:  Evan L Riddle; Annette E Fleckenstein; Glen R Hanson
Journal:  AAPS J       Date:  2005-12-20       Impact factor: 4.009

9.  Peroxynitrite inactivates the human dopamine transporter by modification of cysteine 342: potential mechanism of neurotoxicity in dopamine neurons.

Authors:  Samuel U Park; Jasmine V Ferrer; Jonathan A Javitch; Donald M Kuhn
Journal:  J Neurosci       Date:  2002-06-01       Impact factor: 6.167

Review 10.  Neurotoxicity of methamphetamine and 3,4-methylenedioxymethamphetamine.

Authors:  Laura E Halpin; Stuart A Collins; Bryan K Yamamoto
Journal:  Life Sci       Date:  2013-07-24       Impact factor: 5.037
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