CONCLUSION: In this study, octreotide was not found to be of benefit in the treatment of acute pancreatitis. BACKGROUND:Somatostatin and its long-acting analog octreotide have both been proposed for the treatment of patients with acute pancreatitis, but neither agent has been adequately assessed in patients with severe attacks. METHODS:Fifty-eight patients with moderate or severe acute pancreatitis who were admitted to hospitals within the west of Scotland over an 18-mo period were randomized to receive octreotide, 40 micrograms/h, by continuous i.v. infusion for 5 d, or placebo in addition to standard supportive therapy. RESULTS: There was no significant difference in the incidence of complications (54% octreotide group and 40% placebo group) or mortality (octreotide group 18%; placebo group 20%).
RCT Entities:
CONCLUSION: In this study, octreotide was not found to be of benefit in the treatment of acute pancreatitis. BACKGROUND:Somatostatin and its long-acting analog octreotide have both been proposed for the treatment of patients with acute pancreatitis, but neither agent has been adequately assessed in patients with severe attacks. METHODS: Fifty-eight patients with moderate or severe acute pancreatitis who were admitted to hospitals within the west of Scotland over an 18-mo period were randomized to receive octreotide, 40 micrograms/h, by continuous i.v. infusion for 5 d, or placebo in addition to standard supportive therapy. RESULTS: There was no significant difference in the incidence of complications (54% octreotide group and 40% placebo group) or mortality (octreotide group 18%; placebo group 20%).
Authors: N V Augelli; S M Hussain; M M McKain; R Fietsam; T Bierema; M Fegley; P Bendick; M Villalba; R Lucas; J L Glover Journal: Am Surg Date: 1989-06 Impact factor: 0.688
Authors: Austin L Spitzer; Ruedi F Thoeni; Anthony M Barcia; Michael T Schell; Hobart W Harris Journal: J Gastrointest Surg Date: 2005 Sep-Oct Impact factor: 3.452
Authors: R Mantke; D Schubert; C Röcken; I Paege; W Halangk; B Peters; H Lippert; H-U Schulz Journal: Langenbecks Arch Surg Date: 2008-08-09 Impact factor: 3.445