Literature DB >> 9125641

Pathophysiology of adynamic ileus.

J J Cullen1, D K Caropreso, L L Hemann, M Hinkhouse, J L Conklin, K S Ephgrave.   

Abstract

We hypothesized that the inhibitory neurotransmitters nitric oxide (NO) and vasoactive intestinal peptide (VIP) may play a role in the disrupted gastrointestinal motility of endotoxemia. Strain gauge transducers on the stomach and small intestine of dogs determined interdigestive gastrointestinal motility. Tissue levels of NO synthase and VIP and serum levels of nitrite/nitrate (NO(2)-/NO(3)-) and VIP were measured. Following completion of the baseline studies, dogs were given a single dose of E. coli lipopolysaccharide, 200 microg/kg intravenously, and the studies were repeated for the next three days. Following endotoxin bolus, the migrating motor complex (MMC) was delayed for two days while serum VIP was increased on postendotoxin day 1 and serum NO(2)-/NO(3)- was increased on postendotoxin day 2. There were no changes in gut smooth muscle levels of NO synthase or VIP. We conclude that a single, sublethal dose of endotoxin results in prolongation of the MMC with distinct but independent increases in serum levels of VIP and NO(2)-/NO(3)-.

Entities:  

Mesh：

Substances：

Year:  1997        PMID： 9125641     DOI： 10.1023/a:1018847626936

Source DB:  PubMed          Journal:  Dig Dis Sci        ISSN： 0163-2116            Impact factor:   3.199


  28 in total

1.  Involvement of nitric oxide in nerve-mediated inhibition and action of vasoactive intestinal peptide in colonic smooth muscle.

Authors:  J D Huizinga; J Tomlinson; J Pintin-Quezada
Journal:  J Pharmacol Exp Ther       Date:  1992-02       Impact factor: 4.030

2.  Contractile force transducer for recording muscle activity in unanesthetized animals.

Authors:  P Bass; J N Wiley
Journal:  J Appl Physiol       Date:  1972-04       Impact factor: 3.531

3.  A migrating electric complex of canine small intestine.

Authors:  J H Szurszewski
Journal:  Am J Physiol       Date:  1969-12

Review 4.  Cyclic motor activity; migrating motor complex: 1985.

Authors:  S K Sarna
Journal:  Gastroenterology       Date:  1985-10       Impact factor: 22.682

5.  Release of nitric oxide upon stimulation of nonadrenergic noncholinergic nerves in the rat gastric fundus.

Authors:  G E Boeckxstaens; P A Pelckmans; J J Bogers; H Bult; J G De Man; L Oosterbosch; A G Herman; Y M Van Maercke
Journal:  J Pharmacol Exp Ther       Date:  1991-02       Impact factor: 4.030

6.  NG-methyl-L-arginine inhibits tumor necrosis factor-induced hypotension: implications for the involvement of nitric oxide.

Authors:  R G Kilbourn; S S Gross; A Jubran; J Adams; O W Griffith; R Levi; R F Lodato
Journal:  Proc Natl Acad Sci U S A       Date:  1990-05       Impact factor: 11.205

7.  Non-adrenergic non-cholinergic relaxation mediated by nitric oxide in the canine ileocolonic junction.

Authors:  G E Boeckxstaens; P A Pelckmans; H Bult; J G De Man; A G Herman; Y M Van Maercke
Journal:  Eur J Pharmacol       Date:  1990-11-06       Impact factor: 4.432

8.  Ng-nitro-L-arginine reduces nonadrenergic, noncholinergic relaxations of human gut.

Authors:  D E Burleigh
Journal:  Gastroenterology       Date:  1992-02       Impact factor: 22.682

9.  The effect of inhibitors of the L-arginine/nitric oxide pathway on endotoxin-induced loss of vascular responsiveness in anaesthetized rats.

Authors:  G A Gray; C Schott; G Julou-Schaeffer; I Fleming; J R Parratt; J C Stoclet
Journal:  Br J Pharmacol       Date:  1991-05       Impact factor: 8.739

10.  Effect of endotoxin on canine gastrointestinal motility and transit.

Authors:  J J Cullen; D K Caropreso; K S Ephgrave
Journal:  J Surg Res       Date:  1995-01       Impact factor: 2.192
View more
  8 in total

1.  Acute Intestinal Pseudo-obstruction.

Authors: 
Journal:  Curr Treat Options Gastroenterol       Date:  2000-08

2.  Perforation of the colon after administration of neostigmine.

Authors:  R Mollema; J Jaap Spijkstra; K H Polderman; H P M M Gelissen; A R J Girbes
Journal:  Intensive Care Med       Date:  2004-02-24       Impact factor: 17.440

Review 3.  Can the intestinal dysmotility of critical illness be differentiated from postoperative ileus?

Authors:  Kirk A Caddell; Robert Martindale; Stephen A McClave; Keith Miller
Journal:  Curr Gastroenterol Rep       Date:  2011-08

4.  Neostigmine treatment protocols applied in acute colonic pseudo-obstruction disease: A retrospective comparative study.

Authors:  Ömür İlban; Faruk Çiçekçi; Jale Bengi Çelik; Mehmet Ali Baş; Ateş Duman
Journal:  Turk J Gastroenterol       Date:  2019-03       Impact factor: 1.852

5.  Gastrointestinal dysfunction in mice with a targeted mutation in the gene encoding vasoactive intestinal polypeptide: a model for the study of intestinal ileus and Hirschsprung's disease.

Authors:  V Lelievre; G Favrais; C Abad; H Adle-Biassette; Y Lu; P M Germano; G Cheung-Lau; J R Pisegna; P Gressens; G Lawson; J A Waschek
Journal:  Peptides       Date:  2007-05-18       Impact factor: 3.750

6.  Involvement of serotonin and nitric oxide in endotoxin-induced gastric motility changes in conscious rats.

Authors:  Toshio Watanabe; Takeshi Tomomasa; Hiroaki Kaneko; Atsushi Takahashi; Masahiko Tabata; Sarwar Hussain; Akihiro Morikawa
Journal:  Dig Dis Sci       Date:  2002-06       Impact factor: 3.199

7.  Risk factors for postoperative ileus.

Authors:  Aybala Agac Ay; Suat Kutun; Haluk Ulucanlar; Oguz Tarcan; Abdullah Demir; Abdullah Cetin
Journal:  J Korean Surg Soc       Date:  2011-10-28

8.  Prolonged lipopolysaccharide-induced illness elevates glucagon-like peptide-1 and suppresses peptide YY: A human-randomized cross-over trial.

Authors:  Katrine Brodersen; Maike Mose; Ulla Ramer Mikkelsen; Jens Otto Lunde Jørgensen; Michael Festersen Nielsen; Niels Møller; Anne-Marie Wegeberg; Christina Brock; Bolette Hartmann; Jens Juul Holst; Nikolaj Rittig
Journal:  Physiol Rep       Date:  2022-09
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.