BACKGROUND: Following encouraging reports on the use of granulocyte-macrophage colony-stimulating factor (GM-CSF) to treat wounds in animals and in man, we conducted a study to test the usefulness of this drug in patients with chronic leg ulcers. METHODS: Patients received a single perilesional injection of GM-CSF, the effect of which was observed weekly and compared with that of a placebo injection in a control group. RESULTS: Treated patients fared much better than controls, prompting an early termination of the study: of 16 GM-CSF treated patients, 3 (19%) had their ulcers healed by week 1; 8 (50%) were healed by week 8; only 1 of 9 controls had the ulcer healed by week 1 (11%), and that was the only ulcer of the group that healed at all. We observed no significant side effects or changes in the hematological and biochemical parameters studied. CONCLUSION: GM-CSF seems a very useful drug for the healing of leg ulcers.
RCT Entities:
BACKGROUND: Following encouraging reports on the use of granulocyte-macrophage colony-stimulating factor (GM-CSF) to treat wounds in animals and in man, we conducted a study to test the usefulness of this drug in patients with chronic leg ulcers. METHODS:Patients received a single perilesional injection of GM-CSF, the effect of which was observed weekly and compared with that of a placebo injection in a control group. RESULTS: Treated patients fared much better than controls, prompting an early termination of the study: of 16 GM-CSF treated patients, 3 (19%) had their ulcers healed by week 1; 8 (50%) were healed by week 8; only 1 of 9 controls had the ulcer healed by week 1 (11%), and that was the only ulcer of the group that healed at all. We observed no significant side effects or changes in the hematological and biochemical parameters studied. CONCLUSION:GM-CSF seems a very useful drug for the healing of leg ulcers.
Authors: Elizabeth K Duperret; Christopher A Natale; Christine Monteleon; Ankit Dahal; Todd W Ridky Journal: Cell Cycle Date: 2016-06-13 Impact factor: 4.534
Authors: Zee Upton; Hilary J Wallace; Gary K Shooter; Derek R van Lonkhuyzen; Sim Yeoh-Ellerton; Erin A Rayment; Jacqui M Fleming; Daniel Broszczak; Douglas Queen; R Gary Sibbald; David I Leavesley; Michael C Stacey Journal: Int Wound J Date: 2011-10 Impact factor: 3.315