STUDY DESIGN: Fifty-three human thoracic and lumbar vertebrae were analyzed by dual energy x-ray absorptiomety to obtain projectional (g/cm2) and volumetric (g/cm3) bone mineral density. OBJECTIVES: To determine the effect of volume on the measurement of bone mineral density by DEXA. SUMMARY OF BACKGROUND DATA: Despite the widespread use of dual energy x-ray absorptiomety to measure bone mineral density expressed as grams per projectional unit area (g/cm2), the effect of volume has been ignored in many published biomechanical studies. METHODS: Projectional bone mineral density (g/cm2) of fifty-three human vertebrae was obtained by dual energy x-ray absorptiometry measurement. This was compared to bone mineral density expressed as grams per unit volume. RESULTS: Many specimens with near equal projectional bone mineral density were demonstrated to have significantly different true densities when measured by dual energy x-ray absorptiomety in grams per unit volume. The difference in true bone mineral density for these specimens ranged from 24.1% to 139%. CONCLUSION: The effect of volume on bone mineral density data based on projectional areas can cause very significant perturbations of the data in biomechanical studies.
STUDY DESIGN: Fifty-three human thoracic and lumbar vertebrae were analyzed by dual energy x-ray absorptiomety to obtain projectional (g/cm2) and volumetric (g/cm3) bone mineral density. OBJECTIVES: To determine the effect of volume on the measurement of bone mineral density by DEXA. SUMMARY OF BACKGROUND DATA: Despite the widespread use of dual energy x-ray absorptiomety to measure bone mineral density expressed as grams per projectional unit area (g/cm2), the effect of volume has been ignored in many published biomechanical studies. METHODS: Projectional bone mineral density (g/cm2) of fifty-three human vertebrae was obtained by dual energy x-ray absorptiometry measurement. This was compared to bone mineral density expressed as grams per unit volume. RESULTS: Many specimens with near equal projectional bone mineral density were demonstrated to have significantly different true densities when measured by dual energy x-ray absorptiomety in grams per unit volume. The difference in true bone mineral density for these specimens ranged from 24.1% to 139%. CONCLUSION: The effect of volume on bone mineral density data based on projectional areas can cause very significant perturbations of the data in biomechanical studies.
Authors: Julian L Wichmann; Christian Booz; Stefan Wesarg; Ralf W Bauer; J Matthias Kerl; Sebastian Fischer; Thomas Lehnert; Thomas J Vogl; M Fawad Khan; Konstantinos Kafchitsas Journal: Eur Radiol Date: 2014-12-07 Impact factor: 5.315
Authors: Christian Booz; Philipp C Hofmann; Martin Sedlmair; Thomas G Flohr; Bernhard Schmidt; Tommaso D'Angelo; Simon S Martin; Lukas Lenga; Doris Leithner; Thomas J Vogl; Julian L Wichmann Journal: Eur Radiol Exp Date: 2017-09-20
Authors: E Burian; K Subburaj; M R K Mookiah; A Rohrmeier; D M Hedderich; M Dieckmeyer; M N Diefenbach; S Ruschke; E J Rummeny; C Zimmer; J S Kirschke; D C Karampinos; T Baum Journal: Osteoporos Int Date: 2019-03-22 Impact factor: 4.507
Authors: Vitali Koch; Nils Große Hokamp; Moritz H Albrecht; Leon D Gruenewald; Ibrahim Yel; Jan Borggrefe; Stefan Wesarg; Katrin Eichler; Iris Burck; Tatjana Gruber-Rouh; Lukas Lenga; Thomas J Vogl; Simon S Martin; Julian L Wichmann; Renate M Hammerstingl; Leona S Alizadeh; Christoph Mader; Nicole A Huizinga; Tommaso D'Angelo; Giorgio Ascenti; Silvio Mazziotti; Christian Booz Journal: Eur Radiol Exp Date: 2021-10-05