Literature DB >> 912213

Comparative inhibitory effects of 3-quinuclidinyl benzilate (QNB) and atropine on amylase release from rat pancreas.

J Morisett, K H Ng, G G Poirier.   

Abstract

1 Secrection of amylase from rat pancreas stimualted by urecholine was studied in relation to its inhibition by atropine and 3-quinuclidinyl benzilate (QNB). 2 Urecholine-induced secretion was completely abolished by atropine at 10(-6)M and QNB at 10(-8)M. Significant inhibition could be detected at 10(-8)M atropine and 10(-10)M QNB. 3 The secretory response to pancreozymin was not blocked either by atropine or QNB. 4 The inhibitory effect of QNB remained for at least 90 min after its removal from the incubation medium. 5 It is concluded that QNB is 10 times more potent than atropine in inhibiting pancreatic amylase secretion induced by urecholine.

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Year:  1977        PMID： 912213      PMCID： PMC1667655          DOI： 10.1111/j.1476-5381.1977.tb09745.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  12 in total

1.  An in vitro evaluation of possible cholinergic and adrenergic receptors affecting pancreatic amylase secretion.

Authors:  J A Williams
Journal:  Proc Soc Exp Biol Med       Date:  1975-11

2.  Estimation of nucleic acids.

Authors:  E VOLKIN; W E COHN
Journal:  Methods Biochem Anal       Date:  1954

3.  Biochemical reactions involved in pancreatic enzyme secretion. I. Activation of the adenylate cyclase complex.

Authors:  A R Beaudoin; C Marois; J Dunnigan; J Morisset
Journal:  Can J Physiol Pharmacol       Date:  1974-04       Impact factor: 2.273

4.  Action of cholecystokinin and cholinergic agents on calcium transport in isolated pancreatic acinar cells.

Authors:  J D Gardner; T P Conlon; H L Kleveman; T D Adams; M A Ondetti
Journal:  J Clin Invest       Date:  1975-08       Impact factor: 14.808

Review 5.  Biochemical indentification of the mammalian muscarinic cholinergic receptor.

Authors:  S H Snyder; K J Chang; M J Kuhar; H I Yamamura
Journal:  Fed Proc       Date:  1975-09

6.  Pancreatic acinar cells: acetylcholine-induced membrane depolarization, calcium efflux and amylase release.

Authors:  E K Matthews; O H Petersen; J A Williams
Journal:  J Physiol       Date:  1973-11       Impact factor: 5.182

7.  Pancreatic acinar cells: ionic dependence of the membrane potential and acetycholine-induced depolarization.

Authors:  E K Matthews; O H Petersen
Journal:  J Physiol       Date:  1973-06       Impact factor: 5.182

8.  Calcium efflux and secretion of alpha-amylase from rat pancreas.

Authors:  S Heisler
Journal:  Br J Pharmacol       Date:  1974-11       Impact factor: 8.739

9.  Muscarinic cholinergic binding in rat brain.

Authors:  H I Yamamura; S H Snyder
Journal:  Proc Natl Acad Sci U S A       Date:  1974-05       Impact factor: 11.205

10.  Action of cholecystokinin, cholinergic agents, and A-23187 on accumulation of guanosine 3':5'-monophosphate in dispersed guinea pig pancreatic acinar cells.

Authors:  J P Christophe; E K Frandsen; T P Conlon; G Krishna; J D Gardner
Journal:  J Biol Chem       Date:  1976-08-10       Impact factor: 5.157
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  2 in total

1.  3H-methyl scopolamine binding to dispersed pancreatic acini.

Authors:  H E Appert; T H Chiu; G C Budd; A J Leonardi; J M Howard
Journal:  Cell Tissue Res       Date:  1981       Impact factor: 5.249

2.  Duct, exocrine, and endocrine components of cultured fetal mouse pancreas.

Authors:  K Hirata; T Oku; A E Freeman
Journal:  In Vitro       Date:  1982-09
  2 in total

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