Literature DB >> 9120541

Induction of differentiation by wild-type p53 gene in a human glioma cell line.

T Kokunai1, A Kawamura, N Tamaki.   

Abstract

Wild-type human p53 gene was transfected into the human glioma cell line T-98G. Transfectants were then isolated and characterized for growth potential and differentiation phenotype. Growth suppression, overexpression of GFAP, and accumulation in G1 phase were more commonly observed in transfectants than in T-98G cells. p21WAF1/CIP1 was overexpressed in transfectants, and the binding of PCNA and CDK 2 to p21WAF1/CIP1 were increased in transfectants. These results suggested the roles of p21WAF1/CIP1, PCNA, and CDK2 in regulation of differentiation in glioma cells and the gene transfer of wild-type p53 may be effective for the control of glial differentiation in glioma cells.

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Year:  1997        PMID： 9120541     DOI： 10.1023/a:1005732003296

Source DB:  PubMed          Journal:  J Neurooncol        ISSN： 0167-594X            Impact factor:   4.130


  43 in total

1.  Growth suppression induced by wild-type p53 protein is accompanied by selective down-regulation of proliferating-cell nuclear antigen expression.

Authors:  W E Mercer; M T Shields; D Lin; E Appella; S J Ullrich
Journal:  Proc Natl Acad Sci U S A       Date:  1991-03-01       Impact factor: 11.205

2.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

3.  Transcriptional activation plays a role in the induction of apoptosis by transiently transfected wild-type p53.

Authors:  E Yonish-Rouach; V Deguin; T Zaitchouk; C Breugnot; Z Mishal; J R Jenkins; E May
Journal:  Oncogene       Date:  1995-12-07       Impact factor: 9.867

4.  Cell-cycle inhibition by independent CDK and PCNA binding domains in p21Cip1.

Authors:  Y Luo; J Hurwitz; J Massagué
Journal:  Nature       Date:  1995-05-11       Impact factor: 49.962

5.  Human glial fibrillary acidic protein: complementary DNA cloning, chromosome localization, and messenger RNA expression in human glioma cell lines of various phenotypes.

Authors:  E Bongcam-Rudloff; M Nistér; C Betsholtz; J L Wang; G Stenman; K Huebner; C M Croce; B Westermark
Journal:  Cancer Res       Date:  1991-03-01       Impact factor: 12.701

6.  Wild-type p53 is a cell cycle checkpoint determinant following irradiation.

Authors:  S J Kuerbitz; B S Plunkett; W V Walsh; M B Kastan
Journal:  Proc Natl Acad Sci U S A       Date:  1992-08-15       Impact factor: 11.205

7.  Cell cycle expression and p53 regulation of the cyclin-dependent kinase inhibitor p21.

Authors:  Y Li; C W Jenkins; M A Nichols; Y Xiong
Journal:  Oncogene       Date:  1994-08       Impact factor: 9.867

8.  WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis.

Authors:  W S el-Deiry; J W Harper; P M O'Connor; V E Velculescu; C E Canman; J Jackman; J A Pietenpol; M Burrell; D E Hill; Y Wang
Journal:  Cancer Res       Date:  1994-03-01       Impact factor: 12.701

9.  Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA.

Authors:  J Chen; P K Jackson; M W Kirschner; A Dutta
Journal:  Nature       Date:  1995-03-23       Impact factor: 49.962

10.  The p21 cyclin-dependent kinase inhibitor suppresses tumorigenicity in vivo.

Authors:  Z Y Yang; N D Perkins; T Ohno; E G Nabel; G J Nabel
Journal:  Nat Med       Date:  1995-10       Impact factor: 53.440
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  4 in total

Review 1.  Genetic basis of intramedullary spinal cord tumors and therapeutic implications.

Authors:  A T Parsa; A J Fiore; P C McCormick; J N Bruce
Journal:  J Neurooncol       Date:  2000-05       Impact factor: 4.130

2.  Regulation of the leucocyte chemoattractant receptor FPR in glioblastoma cells by cell differentiation.

Authors:  Jian Huang; Keqiang Chen; Jiaqiang Huang; Wanghua Gong; Nancy M Dunlop; O M Zack Howard; Xiuwu Bian; Yuqi Gao; Ji Ming Wang
Journal:  Carcinogenesis       Date:  2008-11-26       Impact factor: 4.944

3.  Differentiation and growth inhibition of glioma cells induced by transfer of trk A proto-oncogene.

Authors:  T Kokunai; H Iguchi; N Tamaki
Journal:  J Neurooncol       Date:  1999-03       Impact factor: 4.506

4.  PIM1 Inhibition Affects Glioblastoma Stem Cell Behavior and Kills Glioblastoma Stem-like Cells.

Authors:  Carolin Seifert; Ellen Balz; Susann Herzog; Anna Korolev; Sebastian Gaßmann; Heiko Paland; Matthias A Fink; Markus Grube; Sascha Marx; Gabriele Jedlitschky; Mladen V Tzvetkov; Bernhard H Rauch; Henry W S Schroeder; Sandra Bien-Möller
Journal:  Int J Mol Sci       Date:  2021-10-15       Impact factor: 5.923
  4 in total

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