OBJECTIVE: The purpose of this study was to evaluate our use of the association of mifepristone and misoprostol for terminating second and third trimester pregnancies. STUDY DESIGN: One hundred and six patients undergoing termination of pregnancy between January 1993 and June 1995 in our center were studied. Each patient received 600 mg of mifepristone followed 24 h later by 400 microgrammes of misoprostol every 6 h. RESULTS: The average interval from the first administration of misoprostol to expulsion was 12.5 +/- 7.5 h (interval markedly decreased to 9.6 +/- 6.3 h in cases of intrauterine fetal death). CONCLUSION: The efficacy of the association of mifepristone and misoprostol is comparable with that of current regimens with grealer ease of utilization and at a much lower cost.
OBJECTIVE: The purpose of this study was to evaluate our use of the association of mifepristone and misoprostol for terminating second and third trimester pregnancies. STUDY DESIGN: One hundred and six patients undergoing termination of pregnancy between January 1993 and June 1995 in our center were studied. Each patient received 600 mg of mifepristone followed 24 h later by 400 microgrammes of misoprostol every 6 h. RESULTS: The average interval from the first administration of misoprostol to expulsion was 12.5 +/- 7.5 h (interval markedly decreased to 9.6 +/- 6.3 h in cases of intrauterine fetal death). CONCLUSION: The efficacy of the association of mifepristone and misoprostol is comparable with that of current regimens with grealer ease of utilization and at a much lower cost.
Entities:
Keywords:
Abortion, Induced; Biology; Clinical Research; Developed Countries; Endocrine System; Europe; Family Planning; Fertility Control, Postconception; France; Hormone Antagonists; Hormones; Mediterranean Countries; Misoprostol; Physiology; Prostaglandins; Prostaglandins, Synthetic; Research Methodology; Research Report; Ru-486; Western Europe
Authors: M Hoopmann; J Hirneth; J Pauluschke-Fröhlich; B Yazdi; H Abele; D Wallwiener; K O Kagan Journal: Geburtshilfe Frauenheilkd Date: 2014-03-28 Impact factor: 2.915