Literature DB >> 9119069

A domain containing the Cdc42/Rac interactive binding (CRIB) region of p65PAK inhibits transcriptional activation and cell transformation mediated by the Ras-Rac pathway.

S Osada1, M Izawa, T Koyama, S Hirai, S Ohno.   

Abstract

The molecular bases of the versatile functions of Rho-like GTPases are still unknown. Using luciferase assays with rat 3Y1 cells, we found that Rac1 is integrated downstream of Ras in the TRE (TPA response element) activation pathway. Coexpression of a mutant of p65PAK, PAK/RD, lacking the kinase domain but containing the Cdc42/Rac interactive binding (CRIB) region, suppressed the TRE activation and cell transformation caused by constitutively activated forms of Ras (RasV12) and Rac1 (Rac1V12). PAK/RD is a good tool to investigate the signaling pathways in which Rac and Cdc42 are involved.

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Year:  1997        PMID： 9119069     DOI： 10.1016/s0014-5793(97)00139-7

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  7 in total

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Journal:  Mol Cell Proteomics       Date:  2006-12-27       Impact factor: 5.911

2.  Simultaneous tyrosine and serine phosphorylation of STAT3 transcription factor is involved in Rho A GTPase oncogenic transformation.

Authors:  S Aznar; P F Valerón; S V del Rincon; L F Pérez; R Perona; J C Lacal
Journal:  Mol Biol Cell       Date:  2001-10       Impact factor: 4.138

Review 3.  Cdc42: An essential Rho-type GTPase controlling eukaryotic cell polarity.

Authors:  D I Johnson
Journal:  Microbiol Mol Biol Rev       Date:  1999-03       Impact factor: 11.056

4.  R-Ras subfamily proteins elicit distinct physiologic effects and phosphoproteome alterations in neurofibromin-null MPNST cells.

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Review 5.  Molecular pathways: targeting RAC-p21-activated serine-threonine kinase signaling in RAS-driven cancers.

Authors:  Nicole M Baker; Hoi Yee Chow; Jonathan Chernoff; Channing J Der
Journal:  Clin Cancer Res       Date:  2014-09-15       Impact factor: 12.531

Review 6.  Pak protein kinases and their role in cancer.

Authors:  Bettina Dummler; Kazufumi Ohshiro; Rakesh Kumar; Jeffrey Field
Journal:  Cancer Metastasis Rev       Date:  2009-06       Impact factor: 9.264

Review 7.  The role of p21-activated kinases in hepatocellular carcinoma metastasis.

Authors:  Edith Yuk Ting Tse; Yick Pang Ching
Journal:  J Mol Signal       Date:  2014-08-01
  7 in total

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