| Literature DB >> 9118456 |
E Sugino1, S Fujimori, S Hibino, T Choshi, Y Ichihara, Y Sato, T Yamaji, H Tsuboi, N Murata, M Uchida, M Shimamura, T Oikawa.
Abstract
A new anti-angiogenic agent, 17 alpha-acetoxy-9 alpha-fluoro-6 alpha-methylprogesterone (9 alpha-fluoromedoroxyprogesterone acetate [FMPA, 9] was synthetized in a 10-step sequence. FMPA (9) had about two orders of magnitude stronger anti-angiogenic activity than medroxyprogesterone acetate (MPA), as estimated in a bioassay involving chorioallantoic membranes of growing chick embryos.Entities:
Mesh：
Substances：
Year: 1997 PMID： 9118456 DOI： 10.1248/cpb.45.421
Source DB: PubMed Journal: Chem Pharm Bull (Tokyo) ISSN： 0009-2363 Impact factor: 1.645