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Literature DB >> 9118218

Frzb-1 is a secreted antagonist of Wnt signaling expressed in the Spemann organizer.

L Leyns¹, T Bouwmeester, S H Kim, S Piccolo, E M De Robertis.

Abstract

Frzb-1 is a secreted protein containing a domain similar to the putative Wnt-binding region of the frizzled family of transmembrane receptors. Frzb-1 is widely expressed in adult mammalian tissues. In the Xenopus gastrula, it is expressed and regulated as a typical Spemann organizer component. Injection of frzb-1 mRNA blocks expression of XMyoD mRNA and leads to embryos with enlarged heads and shortened trunks. Frzb-1 antagonizes the effects of Xwnt-8 ectopic expression in a non-cell-autonomous manner. Cultured cells transfected with a membrane-tethered form of Wnt-1 bind epitope-tagged Frzb-1 in the 10(-10) M range. The results strengthen the view that the Spemann organizer is a source of secreted inhibitory factors.

Entities: Gene Species

Mesh：

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Year: 1997 PMID： 9118218 PMCID： PMC3061830 DOI： 10.1016/s0092-8674(00)81921-2

Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582

46 in total

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174 in total

1. Inhibition of Wnt activity induces heart formation from posterior mesoderm.

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Journal: Stem Cells Date: 2012-05 Impact factor: 6.277

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Authors: Saori Tsuji; Chikara Hashimoto
Journal: Dev Genes Evol Date: 2005-03-04 Impact factor: 0.900