Does Hebbian synaptic plasticity explain learning-induced sensory plasticity in adult mammals?

Over the last decade, a large number of studies have demonstrated that sensory systems undergo functional reorganizations in adult mammals. In the auditory system, highly specific reorganizations were observed during learning situations in which a particular tone frequency predicts the occurrence of an aversive event. After a brief overview of the specific receptive field changes observed after associative learning in cortical and thalamic neurons, I will raise the question concerning whether or not Hebbian synaptic plasticity adequately accounts for these data. The required conditions for Hebbian synaptic plasticity to act do not seem to be met in situations in which learning-induced receptive field plasticity occurs. This analysis points out the weakness of the traditional Hebbian scheme to provide realistic bases for learning-induced neuronal plasticity and stresses the need to look for other potential mechanisms involving neuromodulators.