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Literature DB >> 911654

A comparative review of the pharmacology of nomifensine.

Abstract

1. Nomifensine is a new substance which showed, in tests for antidepressant activity, a pronounced effect which is quantitatively better than that of the reference substances. 2. With regard to thymoleptic effects in animal studies the effect of nomifensine is similar to that of tricyclic antidepressants, but nomifensine has no pronounced anticholinergic activity. 3. Nomifensine influences the cardiovascular system very slightly. 4. The mechanism of action of nomifensine differs from that of tricyclic antidepressants and must be clearly differentiated from phenylalkyl amines with sympathomimetric activity. 5. Nomifensine is a compound with a special, new profile of action, and thus cannot be calssified in known categories.

Entities: Chemical

Mesh：

Substances：

Year: 1977 PMID： 911654 PMCID： PMC1429114 DOI： 10.1111/j.1365-2125.1977.tb05762.x

Source DB: PubMed Journal: Br J Clin Pharmacol ISSN： 0306-5251 Impact factor: 4.335

8 in total

1. The 6-hydroxydopamine rotational model for the detection of dopamine agonist activity: reliability of effect from different locations of 6-hydroxydopamine.

Authors: B Costall; R J Naylor; C Pycock
Journal: J Pharm Pharmacol Date: 1975-12 Impact factor: 3.765

2. Actions of dopaminergic agonists on motor function.

Authors: B Costall; R J Naylor
Journal: Adv Neurol Date: 1975

3. Effect of nomifensine on motor activity, dopamine turnover rate and cyclic 3',5;-adenosine monophosphate concentrations of rat striatum.

Authors: H J Gerhards; A Carenzi; E Costa
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1974 Impact factor: 3.000

4. 8-Amino-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline, a new antidepressant.

Authors: I Hoffmann
Journal: Arzneimittelforschung Date: 1973-01

5. [8-amino-4-phenyl-1,2,3,4-tetrahydroisoquinolines, a new group of antidepressive psycholeptic drugs].

Authors: I Hoffmann; G Ehrhart; K Schmitt
Journal: Arzneimittelforschung Date: 1971-07

6. A comparison of circling models for the detection of antiparkinson activity.

Authors: B Costall; R J Naylor
Journal: Psychopharmacologia Date: 1975

7. Nomifensine: a potent dopaminergic agonist of antiparkinson potential.

Authors: B Costall; D M Kelly; R J Naylor
Journal: Psychopharmacologia Date: 1975

8. [Proceedings: On the central action of nomifensine (author's transl)].

Authors: J Maj; Z Kapturkiewicz; J Michaluk
Journal: Arzneimittelforschung Date: 1976

8 in total

1. Assessment of the anticholinergic effects of antidepressants in a single-dose cross-over study of salivation and plasma levels.

Authors: L Clemmesen; P L Mikkelsen; H Lund; T G Bolwig; O J Rafaelsen
Journal: Psychopharmacology (Berl) Date: 1984 Impact factor: 4.530

2. Interaction of alcohol with maprotiline or nomifensine: echocardiographic and psychometric effects.

Authors: C Strömberg; A Suokas; T Seppälä
Journal: Eur J Clin Pharmacol Date: 1988 Impact factor: 2.953

Review 3. Catecholamines: role in health and disease.

Authors: R Laverty
Journal: Drugs Date: 1978-11 Impact factor: 9.546

4. A comparison of the pharmacodynamic profiles of nomifensine and amitriptyline in normal subjects.

Authors: M Y Chan; R Ehsanullah; J Wadsworth; J McEwen
Journal: Br J Clin Pharmacol Date: 1980-03 Impact factor: 4.335

5. Effects of acute and chronic treatment with an atypical antidepressant drug, nomifensine, on the sleep-wake activity in rats.

Authors: Z Lelkes; F Obál; G Benedek; G Rubicsek; P Alföldi; F Obál
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1987-02 Impact factor: 3.000