Literature DB >> 91165

Antigenic marker on a functional subpopulation of B cells, controlled by the I-A subregion of the H-2 complex.

B T Huber.   

Abstract

CBA/N mice have an X-linked recessive effect that results in the absence of a subpopulation of B cells carrying the Lyb3 surface marker. It has been shown previously that this marker is present on a mature subset of B cells in all mouse strains. In this paper the Lyb3+ B cell population in C57BL/6 mice was analyzed further. This subset of B cells selectively expresses a surface marker controlled by the I-A subregion of the H-2 complex. A cytotoxic antiserum recognizing this marker was raised by immunizing defective (CBA/N X C57BL/6)F1 male mice with C57BL/6 spleen cells. This antiserum also contained noncytotoxic, non-strain-restricted anti-Lyb3 antibodies. The possible functional relevance of this surface marker is discussed.

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Year:  1979        PMID： 91165      PMCID： PMC383845          DOI： 10.1073/pnas.76.7.3460

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  28 in total

1.  Complementation of H-2-linked Ir genes in the mouse.

Authors:  M E Dorf; B Benacerraf
Journal:  Proc Natl Acad Sci U S A       Date:  1975-09       Impact factor: 11.205

2.  B Cell heterogeneity - difference in the size of B lymphocytes responding to T dependent and T independent antigens.

Authors:  R M Gorczynski; M Feldmann
Journal:  Cell Immunol       Date:  1975-07       Impact factor: 4.868

3.  B-lymphocyte heterogeneity: development and characterization of an alloantiserum which distinguishes B-lymphocyte differentiation alloantigens.

Authors:  A Ahmed; I Scher; S O Sharrow; A H Smith; W E Paul; D H Sachs; K W Sell
Journal:  J Exp Med       Date:  1977-01-01       Impact factor: 14.307

4.  X-linked B-lymphocyte immune defect in CBA/N mice. II. Studies of the mechanisms underlying the immune defect.

Authors:  I Scher; A D Steinberg; A K Berning; W E Paul
Journal:  J Exp Med       Date:  1975-09-01       Impact factor: 14.307

5.  A new I subregion (I-J) marked by a locus (Ia-4) controlling surface determinants on suppressor T lymphocytes.

Authors:  D B Murphy; L A Herzenberg; K Okumura; L A Herzenberg; H O McDevitt
Journal:  J Exp Med       Date:  1976-09-01       Impact factor: 14.307

6.  Selective expression of H-2 (i-region) loci controlling determinants on helper and suppressor T lymphocytes.

Authors:  K Okumura; L A Herzenberg; D B Murphy; H O McDevitt; L A Herzenberg
Journal:  J Exp Med       Date:  1976-09-01       Impact factor: 14.307

7.  Cell interactions between histoincompatible T and B lymphocytes. VII. Cooperative responses between lymphocytes are controlled by genes in the I region of the H-2 complex.

Authors:  D H Katz; M Graves; M E Dorf; H Dimuzio; B Benacerraf
Journal:  J Exp Med       Date:  1975-01-01       Impact factor: 14.307

8.  The role of H-2 linked genes in helper T-cell function. IV. Importance of T-cell genotype and host environment in I-region and Ir gene expression.

Authors:  J W Kappler; P Marrack
Journal:  J Exp Med       Date:  1978-12-01       Impact factor: 14.307

9.  Ontogeny of Ia and IgD on IgM-bearing B lymphocytes in mice.

Authors:  J F Kearney; M D Cooper; J Klein; E R Abney; R M Parkhouse; A R Lawton
Journal:  J Exp Med       Date:  1977-07-01       Impact factor: 14.307

10.  Identification of a B-cell surface structure involved in antigen-dependent triggering: absence of this structure on B cells from CBA/N mutant mice.

Authors:  B Huber; R K Gershon; H Cantor
Journal:  J Exp Med       Date:  1977-01-01       Impact factor: 14.307
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  7 in total

1.  Cell-type-specific cDNA probes and the murine I region: the localization and orientation of Ad alpha.

Authors:  M M Davis; D I Cohen; E A Nielsen; M Steinmetz; W E Paul; L Hood
Journal:  Proc Natl Acad Sci U S A       Date:  1984-04       Impact factor: 11.205

2.  Structural analysis of a new B-cell-differentiation antigen associated with products of the I-A subregion of the H-2 complex.

Authors:  B T Huber; P P Jones; D Thorley-Lawson
Journal:  Proc Natl Acad Sci U S A       Date:  1981-07       Impact factor: 11.205

3.  Xid-defective male (CBA/N X C57BL/6)F1 accessory cells present bovine insulin to long-term cultured F1-restricted T-cells.

Authors:  A B Reske-Kunz; I Iskandar; H G Gattner; D Brandenburg; E Rüde
Journal:  Immunogenetics       Date:  1982       Impact factor: 2.846

4.  Selective loss of antigen-specific Ir gene function in IA mutant B6.C-H-2bm12 is an antigen presenting cell defect.

Authors:  C C Lin; A S Rosenthal; H C Passmore; T H Hansen
Journal:  Proc Natl Acad Sci U S A       Date:  1981-10       Impact factor: 11.205

5.  Subpopulations of B cells distinguished by cell surface expression of Ia antigens. Correlation of Ia and idiotype during activation by cloned Ia-restricted T cells.

Authors:  K Bottomly; B Jones; J Kaye; F Jones
Journal:  J Exp Med       Date:  1983-08-01       Impact factor: 14.307

6.  The xid gene controls Ia.W39-associated immune response gene function.

Authors:  L J Rosenwasser; B T Huber
Journal:  J Exp Med       Date:  1981-05-01       Impact factor: 14.307

7.  Lack of mature B cells in nude mice with X-linked immune deficiency.

Authors:  H H Wortis; L Burkly; D Hughes; S Roschelle; G Waneck
Journal:  J Exp Med       Date:  1982-03-01       Impact factor: 14.307
  7 in total

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