Literature DB >> 9116042

cDNA sequence and chromosomal localization of the NDUFS8 human gene coding for the 23 kDa subunit of the mitochondrial complex I.

V Procaccio1, D Depetris, P Soularue, M G Mattei, J Lunardi, J P Issartel.   

Abstract

We have sequenced the cDNA for the 23 kDa subunit of the human mitochondrial respiratory complex I. The deduced protein consists of 210 amino acids (Mr = 23705 Da) with a 34 amino acid N terminus presumably acting as a presequence for mitochondrial import. The predicted mature protein (Mr = 20290 Da) is 92% identical to the bovine mitochondrial subunit and 72% to the Rhodobacter capsulatus NUOI counterpart. Two clusters of four cysteine residues are conserved among these proteins. The gene (NDUFS8) coding for the human subunit has been mapped to chromosome 11q13.

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Year:  1997        PMID： 9116042     DOI： 10.1016/s0167-4781(97)00020-1

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  9 in total

1.  The X-chromosomal NDUFA1 gene of complex I in mitochondrial encephalomyopathies: tissue expression and mutation detection.

Authors:  J Loeffen; R Smeets; J Smeitink; W Ruitenbeek; A Janssen; E Mariman; R Sengers; F Trijbels; L van den Heuvel
Journal:  J Inherit Metab Dis       Date:  1998-06       Impact factor: 4.982

2.  Sequence analysis of nuclear genes encoding functionally important complex I subunits in children with encephalomyopathy.

Authors:  Reetta Hinttala; Johanna Uusimaa; Anne M Remes; Heikki Rantala; Ilmo E Hassinen; Kari Majamaa
Journal:  J Mol Med (Berl)       Date:  2005-09-03       Impact factor: 4.599

3.  The human nuclear-encoded acyl carrier subunit (NDUFAB1) of the mitochondrial complex I in human pathology.

Authors:  R Triepels; J Smeitink; J Loeffen; R Smeets; C Buskens; F Trijbels; L van den Heuvel
Journal:  J Inherit Metab Dis       Date:  1999-04       Impact factor: 4.982

4.  The human NADH: ubiquinone oxidoreductase NDUFS5 (15 kDa) subunit: cDNA cloning, chromosomal localization, tissue distribution and the absence of mutations in isolated complex I-deficient patients.

Authors:  J Loeffen; R Smeets; J Smeitink; R Triepels; R Sengers; F Trijbels; L van den Heuvel
Journal:  J Inherit Metab Dis       Date:  1999-02       Impact factor: 4.982

5.  Respiratory chain complex I is essential for sexual development in neurospora and binding of iron sulfur clusters are required for enzyme assembly.

Authors:  M Duarte; A Videira
Journal:  Genetics       Date:  2000-10       Impact factor: 4.562

6.  Proteomic analysis of urethral protein expression in an estrogen receptor α-deficient murine model of stress urinary incontinence.

Authors:  Yung-Hsiang Chen; Chao-Jung Chen; Yu-Ning Lin; Yang-Chang Wu; Wen-Tsong Hsieh; Bor-Tsang Wu; Wen-Lung Ma; Wen-Chi Chen; Kao-Sung Tsai; San-Yuan Wu; Chawnshang Chang; Huey-Yi Chen; Shuyuan Yeh
Journal:  World J Urol       Date:  2015-01-11       Impact factor: 4.226

7.  The first nuclear-encoded complex I mutation in a patient with Leigh syndrome.

Authors:  J Loeffen; J Smeitink; R Triepels; R Smeets; M Schuelke; R Sengers; F Trijbels; B Hamel; R Mullaart; L van den Heuvel
Journal:  Am J Hum Genet       Date:  1998-12       Impact factor: 11.025

8.  Gene Expression Contributes to the Recent Evolution of Host Resistance in a Model Host Parasite System.

Authors:  Brian K Lohman; Natalie C Steinel; Jesse N Weber; Daniel I Bolnick
Journal:  Front Immunol       Date:  2017-09-12       Impact factor: 7.561

9.  Role of the Gene ndufs8 Located in Respiratory Complex I from Monascus purpureus in the Cell Growth and Secondary Metabolites Biosynthesis.

Authors:  Xinru Cai; Song Zhang; Jia Lin; Yaxu Wang; Fanyu Ye; Bo Zhou; Qinlu Lin; Jun Liu
Journal:  J Fungi (Basel)       Date:  2022-06-22
  9 in total

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