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Literature DB >> 911601

Cardiovascular effects of a new inotropic agent, U. K. 14275, in patients with coronary heart disease.

I Hutton, W S Hillis, C E Langhan, J M Conely, T D Lawrie.

Abstract

1 The chronotropic and inotropic properties of U.K. 14275, a phosphodiesterase inhibitor were assessed in patients with coronary heart disease. 2 Left ventricular function was assessed in eight patients with acute myocardial infarction using the non-invasive measurement of systolic time intervals. 3 Twelve patients with angina pectoris were studied during diagnostic coronary arteriography. Left ventricular function was assessed using a high fidelity catheter tipped transducer in the left ventricle. 4 In both groups of patients U.K. 14275 infused intravenously in doses of 32, 64, 128 and 256 microgram kg-1 bodyweight min-1 enhanced the contractile state of the left ventricle without altering the heart rate.

Entities: Disease Gene Species

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Year: 1977 PMID： 911601 PMCID： PMC1429153 DOI： 10.1111/j.1365-2125.1977.tb00778.x

Source DB: PubMed Journal: Br J Clin Pharmacol ISSN： 0306-5251 Impact factor: 4.335

14 in total

1. A comparison of cardiovascular effects of dobutamine and isoprenaline after open heart surgery.

Authors: F Kersting; F Follath; R Moulds; J Mucklow; R McCloy; J Sheares; C Dollery
Journal: Br Heart J Date: 1976-06

2. Clinical cardiovascular pharmacology of dobutamine. A selective inotropic catecholamine.

Authors: D Jewitt; J Birkhead; A Mitchell; C Dollery
Journal: Lancet Date: 1974-08-17 Impact factor: 79.321

3. Effects of dobutamine on left ventricular performance, coronary dynamics, and distribution of cardiac output in conscious dogs.

Authors: S F Vatner; R J McRitchie; E Braunwald
Journal: J Clin Invest Date: 1974-05 Impact factor: 14.808

4. Coronary artery occlusion in the conscious dog. Effects of alterations in heart rate and arterial pressure on the degree of myocardial ischemia.

Authors: D R Redwood; E R Smith; S E Epstein
Journal: Circulation Date: 1972-08 Impact factor: 29.690

5. Factors influencing infarct size following experimental coronary artery occlusions.

Authors: P R Maroko; J K Kjekshus; B E Sobel; T Watanabe; J W Covell; J Ross; E Braunwald
Journal: Circulation Date: 1971-01 Impact factor: 29.690

6. Evaluation of the pre-ejection period as an estimate of myocardial contractility in dogs.

Authors: R C Talley; J F Meyer; J L McNay
Journal: Am J Cardiol Date: 1971-04 Impact factor: 2.778

7. Influence of dobutamine on regional myocardial blood flow and ventricular performance during acute and chronic myocardial ischemia in dogs.

Authors: J T Willerson; I Hutton; J T Watson; M R Platt; G H Templeton
Journal: Circulation Date: 1976-05 Impact factor: 29.690

8. Inotropic changes in the left ventricle: the effect of changes in heart rate, aortic pressure and end-diastolic pressure.

Authors: C M Furnival; R J Linden; H M Snow
Journal: J Physiol Date: 1970-12 Impact factor: 5.182

Cardiovascular effects of a new inotropic agent, U. K. 14275, in patients with coronary heart disease.

1. A comparison of cardiovascular effects of dobutamine and isoprenaline after open heart surgery.

2. Clinical cardiovascular pharmacology of dobutamine. A selective inotropic catecholamine.

3. Effects of dobutamine on left ventricular performance, coronary dynamics, and distribution of cardiac output in conscious dogs.

4. Coronary artery occlusion in the conscious dog. Effects of alterations in heart rate and arterial pressure on the degree of myocardial ischemia.

5. Factors influencing infarct size following experimental coronary artery occlusions.

6. Evaluation of the pre-ejection period as an estimate of myocardial contractility in dogs.

7. Influence of dobutamine on regional myocardial blood flow and ventricular performance during acute and chronic myocardial ischemia in dogs.

8. Inotropic changes in the left ventricle: the effect of changes in heart rate, aortic pressure and end-diastolic pressure.

9. Cardiovascular effects of a new inotropic drug in dog and normal man.

10. Effects of cardiac depression and of anesthesia on the myocardial action of a cardiac glycoside.

1. Haemodynamic effects of prenalterol in patients with coronary heart disease.

2. Haemodynamic effects of BM 10.188, a new orally active inotropic agent, in healthy volunteers.