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Literature DB >> 9115392

T-cell receptors: is the repertoire inherently MHC-specific?

C A Janeway¹, A V Chervonsky, D Sant'Angelo.

Abstract

A debate over whether the observed specificity of the naive T-cell receptor repertoire for major histocompatibility complex molecules arises before or after selection within the thymus has apparently been settled in favour of the former by a series of new experiments.

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Year: 1997 PMID： 9115392 DOI： 10.1016/s0960-9822(06)00142-4

Source DB: PubMed Journal: Curr Biol ISSN： 0960-9822 Impact factor: 10.834

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Cited

5 in total

1. T cell receptor interactions with class I heavy-chain influence T cell selection.

Authors: S T Kuhns; M D Tallquist; A J Johnson; Y Mendez-Fernandez; L R Pease
Journal: Proc Natl Acad Sci U S A Date: 2000-01-18 Impact factor: 11.205

2. Coevolution of TCR-MHC interactions: conserved MHC tertiary structure is not sufficient for interactions with the TCR.

Authors: Hye-Jung Kim; Donglin Guo; Derek B Sant'Angelo
Journal: Proc Natl Acad Sci U S A Date: 2005-05-09 Impact factor: 11.205

T-cell receptors: is the repertoire inherently MHC-specific?

1. T cell receptor interactions with class I heavy-chain influence T cell selection.

2. Coevolution of TCR-MHC interactions: conserved MHC tertiary structure is not sufficient for interactions with the TCR.

3. Mek2 is dispensable for mouse growth and development.

4. TCR affinity for self-ligands influences the development and function of encephalitogenic T cells.

Review 5. Dual Role of CD4 in Peripheral T Lymphocytes.