Literature DB >> 9114053

Regulation of the expression of the tissue transglutaminase gene by DNA methylation.

S Lu1, P J Davies.   

Abstract

We have investigated the role of DNA methylation in the regulation of the expression of the human tissue transglutaminase gene. Studies on the methylation of the transglutaminase promoter in normal and neoplastic human cells demonstrated that the promoter is methylated in vivo and hypomethylation of the promoter is correlated with constitutive gene expression. Demethylation of the promoter in vivo by treatment of the cells with 5-azacytidine increased transglutaminase expression and hypermethylation of the promoter in vitro suppressed its activity. These studies suggest that alternations in DNA methylation may be one of the mechanisms regulating the tissue-specific expression of the tissue transglutaminase gene.

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Year:  1997        PMID： 9114053      PMCID： PMC20786          DOI： 10.1073/pnas.94.9.4692

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  40 in total

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Journal:  Cell       Date:  1985-03       Impact factor: 41.582

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Authors:  L Nagy; M Saydak; N Shipley; S Lu; J P Basilion; Z H Yan; P Syka; R A Chandraratna; J P Stein; R A Heyman; P J Davies
Journal:  J Biol Chem       Date:  1996-02-23       Impact factor: 5.157

3.  Identification of promoter region of guinea pig liver transglutaminase gene.

Authors:  N Suto; K Ikura; R Shinagawa; R Sasaki
Journal:  Biochim Biophys Acta       Date:  1993-03-20

4.  Progressive increases in the methylation status and heterochromatinization of the myoD CpG island during oncogenic transformation.

Authors:  W M Rideout; P Eversole-Cire; C H Spruck; C M Hustad; G A Coetzee; F A Gonzales; P A Jones
Journal:  Mol Cell Biol       Date:  1994-09       Impact factor: 4.272

5.  The neuron-restrictive silencer factor (NRSF): a coordinate repressor of multiple neuron-specific genes.

Authors:  C J Schoenherr; D J Anderson
Journal:  Science       Date:  1995-03-03       Impact factor: 47.728

6.  Retinoic acid-induced expression of tissue transglutaminase in mouse peritoneal macrophages.

Authors:  W T Moore; M P Murtaugh; P J Davies
Journal:  J Biol Chem       Date:  1984-10-25       Impact factor: 5.157

7.  Isolation and characterization of the human tissue transglutaminase gene promoter.

Authors:  S Lu; M Saydak; V Gentile; J P Stein; P J Davies
Journal:  J Biol Chem       Date:  1995-04-28       Impact factor: 5.157

8.  Regulation of transglutaminase type II by transforming growth factor-beta 1 in normal and transformed human epidermal keratinocytes.

Authors:  M D George; T M Vollberg; E E Floyd; J P Stein; A M Jetten
Journal:  J Biol Chem       Date:  1990-07-05       Impact factor: 5.157

9.  Expression of tissue transglutaminase in skeletal tissues correlates with events of terminal differentiation of chondrocytes.

Authors:  D Aeschlimann; A Wetterwald; H Fleisch; M Paulsson
Journal:  J Cell Biol       Date:  1993-03       Impact factor: 10.539

10.  Retinoic acid-induced gene expression in normal and leukemic myeloid cells.

Authors:  M P Murtaugh; O Dennison; J P Stein; P J Davies
Journal:  J Exp Med       Date:  1986-05-01       Impact factor: 14.307
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  14 in total

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2.  Methylation status of c-fms oncogene in HCC and its relationship with clinical pathology.

Authors:  J Cui; D H Yang; X J Bi; Z R Fan
Journal:  World J Gastroenterol       Date:  2001-02       Impact factor: 5.742

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Journal:  Int Rev Cell Mol Biol       Date:  2012       Impact factor: 6.813

4.  Folate regulation of axonal regeneration in the rodent central nervous system through DNA methylation.

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7.  Transglutaminase 2 as a cisplatin resistance marker in non-small cell lung cancer.

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Review 8.  Transglutaminases: nature's biological glues.

Authors:  Martin Griffin; Rita Casadio; Carlo M Bergamini
Journal:  Biochem J       Date:  2002-12-01       Impact factor: 3.857

9.  Identification of two GTP-independent alternatively spliced forms of tissue transglutaminase in human leukocytes, vascular smooth muscle, and endothelial cells.

Authors:  Thung-S Lai; Yusha Liu; Weidong Li; Charles S Greenberg
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10.  DNA methylation in transcriptional repression of two differentially expressed X-linked genes, GPC3 and SYBL1.

Authors:  R Huber; R S Hansen; M Strazzullo; G Pengue; R Mazzarella; M D'Urso; D Schlessinger; G Pilia; S M Gartler; M D'Esposito
Journal:  Proc Natl Acad Sci U S A       Date:  1999-01-19       Impact factor: 11.205
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