Literature DB >> 9112693

Anxiolytic-like effects of metabotropic glutamate antagonist (RS)-alpha-methylserine-O-phosphate in rats.

E Chojnacka-Wójcik1, E Tatarczyńska, A Pilc.   

Abstract

Using the conflict drinking Vogel test in rats as a model we examined the anxiolytic-like activity of (RS)-alpha-methylserine-O-phosphate (MSOP) and (RS)-alpha-methylserine-O-phosphate-monophenyl ester (MSOPPE), the antagonists of group III and II of mGluR, respectively, after their intrahippocampal administration. The results indicated that MSOP produced a dose dependent anticonflict effect in rats.

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Year:  1996        PMID: 9112693

Source DB:  PubMed          Journal:  Pol J Pharmacol        ISSN: 1230-6002


  1 in total

1.  Reduced isolation-induced aggressiveness in mice following NAALADase inhibition.

Authors:  L A Lumley; C L Robison; B S Slusher; K Wozniak; M Dawood; J L Meyerhoff
Journal:  Psychopharmacology (Berl)       Date:  2003-11-21       Impact factor: 4.530

  1 in total

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