Literature DB >> 9112596

Mitochondrial DNA polymorphisms in pathologically proven Parkinson's disease.

O Bandmann1, M G Sweeney, S E Daniel, C D Marsden, N W Wood.   

Abstract

To date, five single base pair changes of the mitochondrial DNA have been reported to occur either exclusively or with increased frequency in Caucasian patients with Parkinson's disease (PD) and it has been postulated that these mutations might be casually related to the observed inhibition of mitochondrial respiratory chain function in PD. To evaluate these findings, we analysed the frequency of all five polymorphisms in 100 cases of pathologically proven cases of PD. We were either unable to detect the previously described polymorphisms in our series or found them to be present with the same frequency among controls. Our data do not support the hypothesis of an involvement of the mitochondrial DNA in the pathogenesis of PD.

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Year:  1997        PMID： 9112596     DOI： 10.1007/s004150050082

Source DB:  PubMed          Journal:  J Neurol        ISSN： 0340-5354            Impact factor:   4.849


  29 in total

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Journal:  Neurology       Date:  1994-03       Impact factor: 9.910
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  11 in total

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Review 3.  The unresolved role of mitochondrial DNA in Parkinson's disease: An overview of published studies, their limitations, and future prospects.

Authors:  Amica C Müller-Nedebock; Rebecca R Brennan; Marianne Venter; Ilse S Pienaar; Francois H van der Westhuizen; Joanna L Elson; Owen A Ross; Soraya Bardien
Journal:  Neurochem Int       Date:  2019-06-21       Impact factor: 3.921

4.  Maternal inheritance and mitochondrial DNA variants in familial Parkinson's disease.

Authors:  David K Simon; Nathan Pankratz; Diane K Kissell; Michael W Pauciulo; Cheryl A Halter; Alice Rudolph; Ronald F Pfeiffer; William C Nichols; Tatiana Foroud
Journal:  BMC Med Genet       Date:  2010-04-01       Impact factor: 2.103

5.  Pir1p mediates translocation of the yeast Apn1p endonuclease into the mitochondria to maintain genomic stability.

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6.  Parkinson's disease is associated with oxidative damage to cytoplasmic DNA and RNA in substantia nigra neurons.

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Review 7.  Mitochondrial dysfunction and oxidative stress in Parkinson's disease and monogenic parkinsonism.

Authors:  David N Hauser; Teresa G Hastings
Journal:  Neurobiol Dis       Date:  2012-10-12       Impact factor: 5.996

8.  Mitochondrial DNA polymorphisms and haplogroups in Parkinson's disease and control individuals with a similar genetic background.

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9.  Do mtDNA Mutations Participate in the Pathogenesis of Sporadic Parkinson's Disease?

Authors:  E Kirches
Journal:  Curr Genomics       Date:  2009-12       Impact factor: 2.236

10.  Do somatic mitochondrial DNA mutations contribute to Parkinson's disease?

Authors:  Joanne Clark; Ying Dai; David K Simon
Journal:  Parkinsons Dis       Date:  2011-04-27
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