Literature DB >> 9112087

Decrease in cerebral free magnesium concentration following closed head injury and effects of VA-045 in rats.

M Suzuki1, M Nishina, M Endo, K Matsushita, M Tetsuka, K Shima, S Okuyama.   

Abstract

1. We examined the alterations in cerebral free Mg2+ concentration in closed head injury (CHI) in rats and the effects of VA-045, a novel apovincaminic acid derivative, on them with in vivo 31P-NMR. 2. Free Mg2+ decreased by about 30% within 20 min after head impact and, afterward, it gradually decreased further to reach about 60% of the control level after 3 hr. VA-045 inhibited the decrease. 3. In nonimpacted rats, VA-045 did not alter the free Mg2+ level. 4. The decrease in cerebral free Mg2+ following CHI may be a critical factor in the development of irreversible tissue injury, and VA-045 may prevent it.

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Year:  1997        PMID： 9112087     DOI： 10.1016/s0306-3623(96)00148-6

Source DB:  PubMed          Journal:  Gen Pharmacol        ISSN： 0306-3623


  4 in total

1.  Intracellular magnesium-dependent modulation of gap junction channels formed by neuronal connexin36.

Authors:  Nicolás Palacios-Prado; Gregory Hoge; Alina Marandykina; Lina Rimkute; Sandrine Chapuis; Nerijus Paulauskas; Vytenis A Skeberdis; John O'Brien; Alberto E Pereda; Michael V L Bennett; Feliksas F Bukauskas
Journal:  J Neurosci       Date:  2013-03-13       Impact factor: 6.167

2.  Molecular determinants of magnesium-dependent synaptic plasticity at electrical synapses formed by connexin36.

Authors:  Nicolás Palacios-Prado; Sandrine Chapuis; Alejandro Panjkovich; Julien Fregeac; James I Nagy; Feliksas F Bukauskas
Journal:  Nat Commun       Date:  2014-08-19       Impact factor: 14.919

Review 3.  Assessing Metabolism and Injury in Acute Human Traumatic Brain Injury with Magnetic Resonance Spectroscopy: Current and Future Applications.

Authors:  Matthew G Stovell; Jiun-Lin Yan; Alison Sleigh; Marius O Mada; T Adrian Carpenter; Peter J A Hutchinson; Keri L H Carpenter
Journal:  Front Neurol       Date:  2017-09-12       Impact factor: 4.003

4.  A Systematic Review of Closed Head Injury Models of Mild Traumatic Brain Injury in Mice and Rats.

Authors:  Colleen N Bodnar; Kelly N Roberts; Emma K Higgins; Adam D Bachstetter
Journal:  J Neurotrauma       Date:  2019-03-06       Impact factor: 5.269
  4 in total

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