M J Lynch1, J K Nicholson. 1. Institute of Urology and Nephrology, Birkbeck College, University of London, United Kingdom.
Abstract
BACKGROUND: This is a study of the unusual small molecular components of human prostatic fluid using a non-destructive technique. METHODS: Single pulse high resolution proton MRS of 38 human prostatic fluid samples (12 control, 10 with benign prostatic enlargement, 4 with prostatic cancer, 11 with vasal aplasia, and one with prostatodynia). Regression models for the metabolites measured were made and compared, and correlations were analyzed. RESULTS: A very strong correlation between the secretion of citrate and spermine (r = 0.94), two of the major components of prostatic fluid, was found. The molar ratio was 5:1 citrate: spermine. There was no difference seen between samples obtained by expression or ejaculation. The regression models suggest there is a significant difference (P < 0.02) in the citrate to spermine ratio in prostatic fluid from men with prostate cancer, with a relatively higher level of spermine. CONCLUSIONS: The authors speculate that citrate and spermine secretion is linked and may be forming a novel complex.
BACKGROUND: This is a study of the unusual small molecular components of human prostatic fluid using a non-destructive technique. METHODS: Single pulse high resolution proton MRS of 38 human prostatic fluid samples (12 control, 10 with benign prostatic enlargement, 4 with prostatic cancer, 11 with vasal aplasia, and one with prostatodynia). Regression models for the metabolites measured were made and compared, and correlations were analyzed. RESULTS: A very strong correlation between the secretion of citrate and spermine (r = 0.94), two of the major components of prostatic fluid, was found. The molar ratio was 5:1 citrate: spermine. There was no difference seen between samples obtained by expression or ejaculation. The regression models suggest there is a significant difference (P < 0.02) in the citrate to spermine ratio in prostatic fluid from men with prostate cancer, with a relatively higher level of spermine. CONCLUSIONS: The authors speculate that citrate and spermine secretion is linked and may be forming a novel complex.
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