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Literature DB >> 911015

Chemical mutagenesis: an emerging issue for public health.

Abstract

Chemical mutagens are recognized as prevalent in the environment and a potential threat to the health of future generations. This paper presents an overview of chemical mutagenesis as an issue for public health. Several problems in the determination of risk to human populations are discussed, including difficulties of extrapolating scientific data to humans, the latency period between exposure and recognizable genetic damage, and the large number of chemicals which must be tested. Test systems are described. Possibilities of control through federal regulation are discussed.

Entities: Disease Species

Mesh：

Substances：
Carcinogens
Mutagens

Year: 1977 PMID： 911015 PMCID： PMC1653751 DOI： 10.2105/ajph.67.11.1037

Source DB: PubMed Journal: Am J Public Health ISSN： 0090-0036 Impact factor: 9.308

Keyword Cloud
References

11 in total

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Authors: J McCann; E Choi; E Yamasaki; B N Ames
Journal: Proc Natl Acad Sci U S A Date: 1975-12 Impact factor: 11.205

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Authors:
Journal: Science Date: 1975-02-14 Impact factor: 47.728

Review 3. A tier system approach to mutagen testing.

Authors: W G Flamm
Journal: Mutat Res Date: 1974-08 Impact factor: 2.433

4. An improved bacterial test system for the detection and classification of mutagens and carcinogens.

Authors: B N Ames; F D Lee; W E Durston
Journal: Proc Natl Acad Sci U S A Date: 1973-03 Impact factor: 11.205

5. Mutagenicity of thioxanthenes (hycanthone, lucanthone and four indazole derivatives) at the TK locus in cultured mammalian cells.

Authors: D Clive
Journal: Mutat Res Date: 1974-08 Impact factor: 2.433

6. Occupational disease among operating room personnel: a national study. Report of an Ad Hoc Committee on the Effect of Trace Anesthetics on the Health of Operating Room Personnel, American Society of Anesthesiologists.

Authors:
Journal: Anesthesiology Date: 1974-10 Impact factor: 7.892

Chemical mutagenesis: an emerging issue for public health.

1. Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals.

Review 2. Environmental mutagenic hazards.

Review 3. A tier system approach to mutagen testing.

4. An improved bacterial test system for the detection and classification of mutagens and carcinogens.

5. Mutagenicity of thioxanthenes (hycanthone, lucanthone and four indazole derivatives) at the TK locus in cultured mammalian cells.

6. Occupational disease among operating room personnel: a national study. Report of an Ad Hoc Committee on the Effect of Trace Anesthetics on the Health of Operating Room Personnel, American Society of Anesthesiologists.

7. Editorial: AF-2--food preservative or genetic hazard?

8. The three-tier approach to mutagenicity screening and the concept of radiation-equivalent dose.

9. Angiosarcoma of liver in the manufacture of polyvinyl chloride.

10. Identification of Haemoglobin S in red cells and normoblasts, using fluorescent anti-Hb S antibodies.