RATIONALE AND OBJECTIVE: The study was designed to compare acute and direct cardiotoxicity of gadopentetate dimeglumine, gadoteridol injection, and gadodiamide injection. METHODS: Two consecutive injections of contrast material (0.3 to 1.5 mmol/kg body weight) were given to spontaneously beating, isolated rat hearts. Cardiac function was assessed by measuring left ventricular developed pressure (LVDP), perfusion pressure, and electrocardiographic (ECG) parameters. RESULTS: Gadopentetate dimeglumine decreased LVDP, and its first derivatives (+/- dP/dt max) substantially more than gadodiamide injection. Gadoteridol increased these variables. PR and RT intervals lengthened after 1.5 mmol/kg gadopentetate dimeglumine and gadoteridol injection. Bradycardia and ventricular tachyarrhythmias were seen after injection of 1.5 mmol/kg gadopentetate dimeglumine. Except for isolated ventricular premature beats, gadodiamide injection and gadoteridol injection did not provoke any serious arrhythmia. CONCLUSION: Gadopentatate dimeglumine induced negative inotropy and more pronounced ECG disturbances. Gadoteridol injection and gadodiamide injection induced only small changes in left ventricular inotropy and minor electrophysiologic effects.
RATIONALE AND OBJECTIVE: The study was designed to compare acute and direct cardiotoxicity of gadopentetate dimeglumine, gadoteridol injection, and gadodiamide injection. METHODS: Two consecutive injections of contrast material (0.3 to 1.5 mmol/kg body weight) were given to spontaneously beating, isolated rat hearts. Cardiac function was assessed by measuring left ventricular developed pressure (LVDP), perfusion pressure, and electrocardiographic (ECG) parameters. RESULTS:Gadopentetate dimeglumine decreased LVDP, and its first derivatives (+/- dP/dt max) substantially more than gadodiamide injection. Gadoteridol increased these variables. PR and RT intervals lengthened after 1.5 mmol/kg gadopentetate dimeglumine and gadoteridol injection. Bradycardia and ventricular tachyarrhythmias were seen after injection of 1.5 mmol/kg gadopentetate dimeglumine. Except for isolated ventricular premature beats, gadodiamide injection and gadoteridol injection did not provoke any serious arrhythmia. CONCLUSION:Gadopentatate dimeglumine induced negative inotropy and more pronounced ECG disturbances. Gadoteridol injection and gadodiamide injection induced only small changes in left ventricular inotropy and minor electrophysiologic effects.
Authors: Natalia Sauer; Wojciech Szlasa; Laura Jonderko; Krystyna Głowacka; Katarzyna Karłowicz-Bodalska; Anna Wiela-Hojeńska Journal: Int J Environ Res Public Health Date: 2022-06-09 Impact factor: 4.614
Authors: Yu Chen; Wei Zhu; Fan Shu; Yan Fan; Ning Yang; Tao Wu; Le Ji; Wei Xie; Rengui Bade; Shuyuan Jiang; Xiaolei Liu; Guo Shao; Gang Wu; Xiaoe Jia Journal: Int J Nanomedicine Date: 2020-01-22