Stability in cognitive dysfunctions in schizophrenic patients.

The purpose of the present study was to classify cognitive dysfunctions in schizophrenic subjects according to a trait/state model. A sample of 15 patients was examined on 10 different cognitive measures in two distinctly different phases: an acute psychotic state and partial remission. To determine the degree of dysfunction at the two stages of illness, the schizophrenic patients were also compared to 14 non-psychiatric controls. Six of the 10 measures examined can be classified as cognitive deficits in schizophrenics. Four measures are possibly trait-dependent components: two backward masking scores and two long-term memory measures. A short-term memory measure is the only one that can be classified as an episode-linked factor. The other cognitive deficits found can be characterized as mediating vulnerability factors, i.e. they are more prominent in the acute psychotic state, but do not completely disappear during remission states.