Literature DB >> 9108556

Inhibition of the respiratory chain results in a reversible metabolic arrest in Leishmania promastigotes.

J J Van Hellemond1, A G Tielens.   

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Year:  1997        PMID： 9108556     DOI： 10.1016/s0166-6851(97)02828-4

Source DB:  PubMed          Journal:  Mol Biochem Parasitol        ISSN： 0166-6851            Impact factor:   1.759


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  16 in total

1.  Isotopomer profiling of Leishmania mexicana promastigotes reveals important roles for succinate fermentation and aspartate uptake in tricarboxylic acid cycle (TCA) anaplerosis, glutamate synthesis, and growth.

Authors:  Eleanor C Saunders; William W Ng; Jennifer M Chambers; Milica Ng; Thomas Naderer; Jens O Krömer; Vladimir A Likic; Malcolm J McConville
Journal:  J Biol Chem       Date:  2011-06-02       Impact factor: 5.157

2.  The 8-aminoquinoline analogue sitamaquine causes oxidative stress in Leishmania donovani promastigotes by targeting succinate dehydrogenase.

Authors:  Luis Carvalho; Juan Román Luque-Ortega; Carmen López-Martín; Santiago Castanys; Luis Rivas; Francisco Gamarro
Journal:  Antimicrob Agents Chemother       Date:  2011-06-13       Impact factor: 5.191

3.  Tafenoquine, an antiplasmodial 8-aminoquinoline, targets leishmania respiratory complex III and induces apoptosis.

Authors:  Luis Carvalho; Juan Román Luque-Ortega; José Ignacio Manzano; Santiago Castanys; Luis Rivas; Francisco Gamarro
Journal:  Antimicrob Agents Chemother       Date:  2010-09-13       Impact factor: 5.191

4.  Trypanosomatidae produce acetate via a mitochondrial acetate:succinate CoA transferase.

Authors:  J J Van Hellemond; F R Opperdoes; A G Tielens
Journal:  Proc Natl Acad Sci U S A       Date:  1998-03-17       Impact factor: 11.205

5.  Characterization of a Leishmania stage-specific mitochondrial membrane protein that enhances the activity of cytochrome c oxidase and its role in virulence.

Authors:  Ranadhir Dey; Claudio Meneses; Poonam Salotra; Shaden Kamhawi; Hira L Nakhasi; Robert Duncan
Journal:  Mol Microbiol       Date:  2010-05-24       Impact factor: 3.501

6.  Miltefosine (hexadecylphosphocholine) inhibits cytochrome c oxidase in Leishmania donovani promastigotes.

Authors:  Juan Román Luque-Ortega; Luis Rivas
Journal:  Antimicrob Agents Chemother       Date:  2007-02-05       Impact factor: 5.191

7.  Targeting the Cytochrome bc1 Complex of Leishmania Parasites for Discovery of Novel Drugs.

Authors:  Diana Ortiz; Isaac Forquer; Jan Boitz; Radika Soysa; Carolyn Elya; Audrey Fulwiler; Aaron Nilsen; Tamsen Polley; Michael K Riscoe; Buddy Ullman; Scott M Landfear
Journal:  Antimicrob Agents Chemother       Date:  2016-07-22       Impact factor: 5.191

8.  Globin-coupled heme containing oxygen sensor soluble adenylate cyclase in Leishmania prevents cell death during hypoxia.

Authors:  Sumit Sen Santara; Jayasree Roy; Supratim Mukherjee; Moumita Bose; Rina Saha; Subrata Adak
Journal:  Proc Natl Acad Sci U S A       Date:  2013-09-30       Impact factor: 11.205

9.  An essential type I nitroreductase from Leishmania major can be used to activate leishmanicidal prodrugs.

Authors:  Andrew A Voak; Vithurshaa Gobalakrishnapillai; Karin Seifert; Edina Balczo; Longqin Hu; Belinda S Hall; Shane R Wilkinson
Journal:  J Biol Chem       Date:  2013-08-14       Impact factor: 5.157

10.  Leishmania donovani develops resistance to drug combinations.

Authors:  Raquel García-Hernández; José Ignacio Manzano; Santiago Castanys; Francisco Gamarro
Journal:  PLoS Negl Trop Dis       Date:  2012-12-20
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