| Literature DB >> 9108306 |
A D Howard1, C Tan, L L Shiao, O C Palyha, K K McKee, D H Weinberg, S D Feighner, M A Cascieri, R G Smith, L H Van Der Ploeg, K A Sullivan.
Abstract
Galanin (GAL) is a widely distributed neuropeptide with diverse biological effects including modulation of hormone release, antinociception and modification of feeding behavior. Its effects are mediated through G-protein-coupled receptors (GPCR) for which only a single type has been cloned, GAL receptor 1 (GALR1). We describe the cloning of a second galanin receptor type, GALR2, from rat hypothalamus. The GALR2 amino acid sequence is 38% identical to GALR1 and is pharmacologically similar to GALR1 when expressed in COS-7 cells. GALR2 is encoded by a single gene containing at least one intron and expressed in a diverse range of tissues.Entities:
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Year: 1997 PMID： 9108306 DOI： 10.1016/s0014-5793(97)00196-8
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124