Fibrous dysplasia of bone: case report with autopsy study 80 years after the original clinical recognition of the bone lesions.

We present a report of the histological features of the bone lesions in a case of polyostotic fibrous dysplasia studied at autopsy in a patient aged 88 years. While much of the fibrous tissue of the lesions contained the trabeculae of non-lamellar bone that are a feature of fibrous dysplasia in young patients, other parts of the lesions showed evidence of osteoclastic remodelling of bone trabeculae, and even of the replacement of some of these structures by mature lamellar bone.