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Literature DB >> 91026

Effect of oral contraceptives on platelet noradrenaline and5-hydroxytryptamine receptors and aggregation.

J R Peters, J M Elliott, D G Grahame-Smith.

Abstract

Characteristics of receptor sites on platelets for noradrenaline (NA) and serotonin (5-HT) changed significantly between day 21 and day 28 of treatment in healthy women taking oral contraceptives. NA-induced and 5-HT-induced platelet aggregation and 5-HT uptake vaired accordingly. In untreated women with normal cycles no changes in either receptor site or in platelet function occurred between the luteal and postmenstrual phases. It is concluded that the observed changes are due to a pharmacological effect of the oral contraceptive rather than a normal physiological variation.

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Year: 1979 PMID： 91026 DOI： 10.1016/s0140-6736(79)92626-6

Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321

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Cited

11 in total

Review 1. [The antibaby pill as a risk factor for thrombosis: are the molecular mechanisms known?].

Authors: P P Nawroth; R Ziegler
Journal: Klin Wochenschr Date: 1991-05-24

2. The effects of clonidine on blood pressure, catecholamine and growth hormone release in hypogonadal men is preserved and not influenced by testosterone replacement therapy.

Authors: G Del Rio; C Carani; A Velardo; M Procopio; G Zizzo; P Savio; R Mantovani; P Marrama; E Ghigo
Journal: J Endocrinol Invest Date: 1996-09 Impact factor: 4.256

Effect of oral contraceptives on platelet noradrenaline and5-hydroxytryptamine receptors and aggregation.

Review 1. [The antibaby pill as a risk factor for thrombosis: are the molecular mechanisms known?].

2. The effects of clonidine on blood pressure, catecholamine and growth hormone release in hypogonadal men is preserved and not influenced by testosterone replacement therapy.

Review 3. Platelet alpha-adrenoceptors--a valid model for brain or vascular adrenoceptors?

4. Influence of oestradiol on alpha 2-adrenoceptor binding sites on intact platelets of young male volunteers.

5. Lack of effect of oestradiol implant on platelet imipramine and 5-HT2 receptor binding in menopausal subjects.

6. The effects of chronic ritanserin treatment on sleep and the neuroendocrine response to L-tryptophan.

Review 7. Radioligand binding studies of adrenergic receptors and their clinical relevance.

8. Increased numbers of alpha receptors in sympathetic denervation supersensitivity in man.

9. [Clinical aspects of pathophysiological mechanisms in migraine.].

10. The binding characteristics of [3H]-dihydroergocryptine on intact human platelets.