A Pogacnik1, N Zidar. 1. Department of Cytopathology, Institute of Oncology, Ljubljana, Zaloska, Slovenia.
Abstract
BACKGROUND: Primary malignant rhabdoid tumor (MRT) of the liver is a rare tumor of early infancy, with a grim prognosis. CASE: A 17-month-old female presented with a palpable mass in the upper right side of the abdomen. Ultrasonographically guided fine needle aspiration biopsy of the tumor contained malignant cells with medium-sized, vesicular nuclei; prominent nucleoli; and well-defined cytoplasm exhibiting paranuclear, dense inclusions. These inclusions reacted positively with cytokeratin and vimentin. Ultrastructural examination showed the presence of intermediate cytoplasmic filaments. CONCLUSION: Cytomorphologic and immunocytochemical characteristics permit the preoperative differentiation of MRT from other malignant tumors of childhood. That facilitates treatment planning and precludes unnecessary surgical intervention.
BACKGROUND:Primary malignant rhabdoid tumor (MRT) of the liver is a rare tumor of early infancy, with a grim prognosis. CASE: A 17-month-old female presented with a palpable mass in the upper right side of the abdomen. Ultrasonographically guided fine needle aspiration biopsy of the tumor contained malignant cells with medium-sized, vesicular nuclei; prominent nucleoli; and well-defined cytoplasm exhibiting paranuclear, dense inclusions. These inclusions reacted positively with cytokeratin and vimentin. Ultrastructural examination showed the presence of intermediate cytoplasmic filaments. CONCLUSION: Cytomorphologic and immunocytochemical characteristics permit the preoperative differentiation of MRT from other malignant tumors of childhood. That facilitates treatment planning and precludes unnecessary surgical intervention.
Authors: I Nakamura; K Nakano; K Nakayama; Y Ishii; K Ohta; M Takahashi; T Yamada; K Yamaguchi; H Sakuma; A Tsuchiya; S Takenoshita Journal: Surg Today Date: 1999 Impact factor: 2.549