Literature DB >> 9099796

Positive selection of thymocytes bearing alpha beta T cell receptors.

P Marrack1, J Kappler.   

Abstract

The past year has been marked by the application of new technologies to study thymocyte development. These studies have shown that positive selection affects a surprisingly large proportion of thymocytes, and now are beginning to investigate the affinities/avidities of the reactions involved. The lengthy controversy over how thymocytes decide whether to express CD4 or CD8 has taken a new turn with the discovery that levels of expression of the fate-determining protein Notch may affect the decision.

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Year:  1997        PMID： 9099796     DOI： 10.1016/s0952-7915(97)80144-6

Source DB:  PubMed          Journal:  Curr Opin Immunol        ISSN： 0952-7915            Impact factor:   7.486


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