Literature DB >> 909805

Fluorination of 6-methyluracil and its nlcleosides.

D Cech, G Herrmann, A Holy.   

Abstract

6-Methyluracil and its perbenzoylated 1-(beta-D-ribofuranosyl) and 1-(2-deoxy-beta-D-ribofuranosyl) derivatives afford on treatment with elemental fluorine in acetic acid solutions, the corresponding derivatives of 5-fluoro-6-methyluracil and 5-fluoro-6-fluoromethyluracil. The free nucleosides have been obtained from the protected derivatives by methanolysis. The CH2F linkage in 5-fluoro-6-fluoromethyluracil derivatives is stable towards hydrolysis and nucleophilic agents.

Entities:  

Mesh：

Substances：

Year:  1977        PMID： 909805      PMCID： PMC342648          DOI： 10.1093/nar/4.9.3259

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  3 in total

1.  Use of sulfur tetrafluoride in syntheses of potential anticancer agents.

Authors:  M P MERTES; S E SAHEB
Journal:  J Pharm Sci       Date:  1963-05       Impact factor: 3.534

2.  Nucleosides. 78. Synthesis of some 6-substituted uracils and uridines by the Wittig reaction.

Authors:  R S Klein; J J Fox
Journal:  J Org Chem       Date:  1972-12-29       Impact factor: 4.354

3.  Synthesis of substituted 5-fluoro-5,6-dihydropyrimidines.

Authors:  D Cech; L Hein; R Wuttke; M von Janta-Lipinski; A Otto; P Langen
Journal:  Nucleic Acids Res       Date:  1975-11       Impact factor: 16.971
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.