Literature DB >> 9097987

MHC class II antigen-associated invariant chain on renal cell cancer may contribute to the anti-tumor immune response of the host.

T Saito1, M Kimura, T Kawasaki, S Sato, Y Tomita.   

Abstract

To investigate the association between renal cell cancer (RCC) and the host immune system, we examined the expression of invariant chain (Ii) and HLA-DR on renal cancer. Immunohistochemically, Ii was detected in 53 of the 60 cases of RCC. Significant correlation was found between the expression of Ii and the degree of lymphocyte infiltration. Flow cytometric analysis for HLA-DR and Ii on RCC cell line (ACHN) showed no positive cells, whereas interferon (IFN)-gamma treatment induced HLA-DR. Immunoprecipitation showed the presence of cytoplasmic Ii in ACHN cells. In addition, IFN-gamma-treated ACHN cells showed more intense signals than untreated cells. These results suggest that Ii associated with class II antigens on RCC may contribute to the anti-tumor immune response of the host and that IFN-gamma, which is administered for the treatment of cancer, may increase the immunogenicity of RCC.

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Year:  1997        PMID： 9097987     DOI： 10.1016/s0304-3835(97)04754-x

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  6 in total

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Journal:  J Mol Diagn       Date:  2005-05       Impact factor: 5.568

2.  Expression profiling of renal epithelial neoplasms: a method for tumor classification and discovery of diagnostic molecular markers.

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3.  Effect of invariant chain on major histocompatibility complex class I molecule expression and stability on human breast tumor cell lines.

Authors:  Xuede Lin; Xiaojian Wang; Haley L Capek; Laura C Simone; Amit Tuli; Chantey R Morris; Adrian J Reber; Joyce C Solheim
Journal:  Cancer Immunol Immunother       Date:  2008-10-01       Impact factor: 6.968

Review 4.  Association of intracellular proteins with folded major histocompatibility complex class I molecules.

Authors:  Chantey R Morris; Adrian J Reber; Jason L Petersen; Shanna E Vargas; Joyce C Solheim
Journal:  Immunol Res       Date:  2004       Impact factor: 2.829

5.  Therapeutic Effects of Dietary Soybean Genistein on Triple-Negative Breast Cancer via Regulation of Epigenetic Mechanisms.

Authors:  Manvi Sharma; Itika Arora; Min Chen; Huixin Wu; Michael R Crowley; Trygve O Tollefsbol; Yuanyuan Li
Journal:  Nutrients       Date:  2021-11-04       Impact factor: 5.717

6.  HIF-1α and HIF-2α differently regulate tumour development and inflammation of clear cell renal cell carcinoma in mice.

Authors:  Rouven Hoefflin; Sabine Harlander; Silvia Schäfer; Patrick Metzger; Fengshen Kuo; Désirée Schönenberger; Mojca Adlesic; Asin Peighambari; Philipp Seidel; Chia-Yi Chen; Miguel Consenza-Contreras; Andreas Jud; Bernd Lahrmann; Niels Grabe; Danijela Heide; Franziska M Uhl; Timothy A Chan; Justus Duyster; Robert Zeiser; Christoph Schell; Mathias Heikenwalder; Oliver Schilling; A Ari Hakimi; Melanie Boerries; Ian J Frew
Journal:  Nat Commun       Date:  2020-08-17       Impact factor: 14.919
  6 in total

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