Literature DB >> 9097981

The Annonaceous acetogenin bullatacin is cytotoxic against multidrug-resistant human mammary adenocarcinoma cells.

N H Oberlies1, V L Croy, M L Harrison, J L McLaughlin.   

Abstract

Cytotoxic effects of the Annonaceous acetogenin, bullatacin, were studied in multidrug-resistant (MDR) human mammary adenocarcinoma (MCF-7/Adr) cells vs. the parental non-resistant wild type (MCF-7/wt) cells. Bullatacin was effectively cytotoxic to the MCF-7/Adr cells while it was more cytostatic to the MCF-7/wt cells. ATP depletion is the mode of action of the Annonaceous acetogenins, and these agents offer a special advantage in the chemotherapeutic treatment of MDR tumors that have ATP-dependent mechanisms.

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Year:  1997        PMID： 9097981     DOI： 10.1016/s0304-3835(97)04716-2

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  18 in total

1.  Synthesis of (+)-bullatacin via the highly diastereoselective [3+2] annulation reaction of a racemic aldehyde and a nonracemic allylsilane.

Authors:  Jennifer M Tinsley; Eric Mertz; Pek Y Chong; Robert-André F Rarig; William R Roush
Journal:  Org Lett       Date:  2005-09-15       Impact factor: 6.005

2.  Anti-cancer analogues ME-143 and ME-344 exert toxicity by directly inhibiting mitochondrial NADH: ubiquinone oxidoreductase (Complex I).

Authors:  Sze Chern Lim; Kirstyn T Carey; Matthew McKenzie
Journal:  Am J Cancer Res       Date:  2015-01-15       Impact factor: 6.166

Review 3.  Mitochondrial metabolism inhibitors for cancer therapy.

Authors:  Emma E Ramsay; Philip J Hogg; Pierre J Dilda
Journal:  Pharm Res       Date:  2011-09-15       Impact factor: 4.200

Review 4.  Emerging therapeutic potential of graviola and its constituents in cancers.

Authors:  Asif Khurshid Qazi; Jawed A Siddiqui; Rahat Jahan; Sanjib Chaudhary; Larry A Walker; Zafar Sayed; Dwight T Jones; Surinder K Batra; Muzafar A Macha
Journal:  Carcinogenesis       Date:  2018-04-05       Impact factor: 4.944

5.  Antifungal activity screening of fractions from Annona cherimola Mill. leaf extract against Fusarium oxysporum.

Authors:  Manuel Méndez-Chávez; Carlos A Ledesma-Escobar; Madeleine Hidalgo-Morales; Guadalupe Del Carmen Rodríguez-Jimenes; Victor José Robles-Olvera
Journal:  Arch Microbiol       Date:  2022-05-17       Impact factor: 2.552

6.  Bullatacin triggered ABCB1-overexpressing cell apoptosis via the mitochondrial-dependent pathway.

Authors:  Yong-Ju Liang; Xu Zhang; Chun-Ling Dai; Jian-Ye Zhang; Yan-Yan Yan; Mu-Sheng Zeng; Li-Ming Chen; Li-Wu Fu
Journal:  J Biomed Biotechnol       Date:  2009-07-21

7.  Alteration of the bis-tetrahydrofuran core stereochemistries in asimicin can affect the cytotoxicity.

Authors:  Subhash C Sinha; Zhiyong Chen; Zheng-Zheng Huang; Eiko Nakamaru-Ogiso; Halina Pietraszkiewicz; Matthew Edelstein; Frederick Valeriote
Journal:  J Med Chem       Date:  2008-11-27       Impact factor: 7.446

Review 8.  Modulation of inflammatory pathways, medicinal uses and toxicities of Uvaria species: potential role in the prevention and treatment of inflammation.

Authors:  Juriyati Jalil; Ali Attiq; Chiew Chia Hui; Lui Jin Yao; Nurul Aimi Zakaria
Journal:  Inflammopharmacology       Date:  2020-07-02       Impact factor: 4.473

9.  Goniothalamus species: a source of drugs for the treatment of cancers and bacterial infections?

Authors:  Christophe Wiart
Journal:  Evid Based Complement Alternat Med       Date:  2007-09       Impact factor: 2.629

10.  Recent progress on the total synthesis of acetogenins from Annonaceae.

Authors:  Nianguang Li; Zhihao Shi; Yuping Tang; Jianwei Chen; Xiang Li
Journal:  Beilstein J Org Chem       Date:  2008-12-05       Impact factor: 2.883
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