Literature DB >> 9096988

Catheter survival during long-term insulin therapy with an implanted programmable pump. The Implantable Insulin Pump Trial Study Group.

M Scavini1, L Galli, S Reich, R P Eaton, M A Charles, F L Dunn.   

Abstract

OBJECTIVE: To survey catheter complications and to analyze catheter survival during long-term intraperitoneal and intravenous insulin therapy with an implanted programmable pump with a sideport. RESEARCH DESIGN AND METHODS: Catheter occlusions were documented by measuring dynamic catheter resistance. Catheter migrations or breaks were demonstrated by X ray. When flushing the catheter with buffer solution through the sideport failed to clear the occlusion, catheters were replaced or laparoscopy was performed for the excision of fibrous tissue growth. Broken or migrated catheters were replaced.
RESULTS: Occlusions were the most common catheter complications, and the majority of them (79% intraperitoneal and 84% intravenous) were cleared by flushing the catheter. Survival at 3 years was significantly higher for intraperitoneal catheters compared with intravenous catheters (60% intraperitoneal and 22% intravenous).
CONCLUSIONS: Nonsurgical management of catheter occlusions contributed to extend catheter lifetime. Intraperitoneal catheters have a lower morbidity and a higher survival than intravenous catheters.

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Year:  1997        PMID: 9096988     DOI: 10.2337/diacare.20.4.610

Source DB:  PubMed          Journal:  Diabetes Care        ISSN: 0149-5992            Impact factor:   19.112


  3 in total

Review 1.  Finding the right route for insulin delivery - an overview of implantable pump therapy.

Authors:  Lia Bally; Hood Thabit; Roman Hovorka
Journal:  Expert Opin Drug Deliv       Date:  2016-12-07       Impact factor: 6.648

2.  Complications of continuous intraperitoneal insulin infusion with an implantable pump.

Authors:  Peter R van Dijk; Susan Jj Logtenberg; Klaas H Groenier; Jan Willem Haveman; Nanno Kleefstra; Henk Jg Bilo
Journal:  World J Diabetes       Date:  2012-08-15

3.  Dosage form development, in vitro release kinetics, and in vitro-in vivo correlation for leuprolide released from an implantable multi-reservoir array.

Authors:  James H Prescott; Timothy J Krieger; Sara Lipka; Mark A Staples
Journal:  Pharm Res       Date:  2007-03-27       Impact factor: 4.580

  3 in total

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