Literature DB >> 9096335

Essential role of the tyrosine kinase substrate phospholipase C-gamma1 in mammalian growth and development.

Q S Ji1, G E Winnier, K D Niswender, D Horstman, R Wisdom, M A Magnuson, G Carpenter.   

Abstract

The activation of many tyrosine kinases leads to the phosphorylation and activation of phospholipase C-gamma1 (PLC-gamma1). To examine the biological function of this protein, homologous recombination has been used to selectively disrupt the Plcg1 gene in mice. Homozygous disruption of Plcg1 results in embryonic lethality at approximately embryonic day (E) 9.0. Histological analysis indicates that Plcg1 (-/-) embryos appear normal at E 8.5 but fail to continue normal development and growth beyond E 8.5-E9.0. These results clearly demonstrate that PLC-gamma1 with, by inference, its capacity to mobilize second messenger molecules is an essential signal transducing molecule whose absence is not compensated by other signaling pathways or other genes encoding PLC isozymes.

Entities:  

Mesh：

Substances：

Year:  1997        PMID： 9096335      PMCID： PMC20311          DOI： 10.1073/pnas.94.7.2999

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  23 in total

1.  Elevated content of the tyrosine kinase substrate phospholipase C-gamma 1 in primary human breast carcinomas.

Authors:  C L Arteaga; M D Johnson; G Todderud; R J Coffey; G Carpenter; D L Page
Journal:  Proc Natl Acad Sci U S A       Date:  1991-12-01       Impact factor: 11.205

2.  Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene.

Authors:  V L Tybulewicz; C E Crawford; P K Jackson; R T Bronson; R C Mulligan
Journal:  Cell       Date:  1991-06-28       Impact factor: 41.582

3.  Platelet-derived growth factor increases the in vivo activity of phospholipase C-gamma 1 and phospholipase C-gamma 2.

Authors:  L Sultzman; C Ellis; L L Lin; T Pawson; J Knopf
Journal:  Mol Cell Biol       Date:  1991-04       Impact factor: 4.272

4.  A second type of rat phosphoinositide-specific phospholipase C containing a src-related sequence not essential for phosphoinositide-hydrolyzing activity.

Authors:  Y Emori; Y Homma; H Sorimachi; H Kawasaki; O Nakanishi; K Suzuki; T Takenawa
Journal:  J Biol Chem       Date:  1989-12-25       Impact factor: 5.157

5.  High-efficiency expression/cloning of epidermal growth factor-receptor-binding proteins with Src homology 2 domains.

Authors:  B Margolis; O Silvennoinen; F Comoglio; C Roonprapunt; E Skolnik; A Ullrich; J Schlessinger
Journal:  Proc Natl Acad Sci U S A       Date:  1992-10-01       Impact factor: 11.205

6.  Point mutation of an FGF receptor abolishes phosphatidylinositol turnover and Ca2+ flux but not mitogenesis.

Authors:  K G Peters; J Marie; E Wilson; H E Ives; J Escobedo; M Del Rosario; D Mirda; L T Williams
Journal:  Nature       Date:  1992-08-20       Impact factor: 49.962

7.  Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis.

Authors:  M Mohammadi; C A Dionne; W Li; N Li; T Spivak; A M Honegger; M Jaye; J Schlessinger
Journal:  Nature       Date:  1992-08-20       Impact factor: 49.962

8.  Isolation of a putative phospholipase C gene of Drosophila, norpA, and its role in phototransduction.

Authors:  B T Bloomquist; R D Shortridge; S Schneuwly; M Perdew; C Montell; H Steller; G Rubin; W L Pak
Journal:  Cell       Date:  1988-08-26       Impact factor: 41.582

9.  Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines.

Authors:  G J TODARO; H GREEN
Journal:  J Cell Biol       Date:  1963-05       Impact factor: 10.539

10.  Identification of two C-terminal autophosphorylation sites in the PDGF beta-receptor: involvement in the interaction with phospholipase C-gamma.

Authors:  L Rönnstrand; S Mori; A K Arridsson; A Eriksson; C Wernstedt; U Hellman; L Claesson-Welsh; C H Heldin
Journal:  EMBO J       Date:  1992-11       Impact factor: 11.598
View more
  73 in total

1.  Regulation of phospholipase Cgamma in the mesolimbic dopamine system by chronic morphine administration.

Authors:  D H Wolf; S Numan; E J Nestler; D S Russell
Journal:  J Neurochem       Date:  1999-10       Impact factor: 5.372

2.  Vav1 regulates phospholipase cgamma activation and calcium responses in mast cells.

Authors:  T S Manetz; C Gonzalez-Espinosa; R Arudchandran; S Xirasagar; V Tybulewicz; J Rivera
Journal:  Mol Cell Biol       Date:  2001-06       Impact factor: 4.272

3.  Epo-induced erythroid maturation is dependent on Plcγ1 signaling.

Authors:  T M Schnöder; P Arreba-Tutusaus; I Griehl; L Bullinger; M Buschbeck; S W Lane; K Döhner; C Plass; D B Lipka; F H Heidel; T Fischer
Journal:  Cell Death Differ       Date:  2014-11-14       Impact factor: 15.828

4.  Pleiotropic contributions of phospholipase C-gamma1 (PLC-gamma1) to T-cell antigen receptor-mediated signaling: reconstitution studies of a PLC-gamma1-deficient Jurkat T-cell line.

Authors:  B J Irvin; B L Williams; A E Nilson; H O Maynor; R T Abraham
Journal:  Mol Cell Biol       Date:  2000-12       Impact factor: 4.272

Review 5.  The phospholipase C isozymes and their regulation.

Authors:  Aurelie Gresset; John Sondek; T Kendall Harden
Journal:  Subcell Biochem       Date:  2012

6.  Phospholipase C-gamma contains introns shared by src homology 2 domains in many unrelated proteins.

Authors:  Charlene M Manning; Wendy R Mathews; Leah P Fico; Justin R Thackeray
Journal:  Genetics       Date:  2003-06       Impact factor: 4.562

Review 7.  Signal transduction by vascular endothelial growth factor receptors.

Authors:  Sina Koch; Lena Claesson-Welsh
Journal:  Cold Spring Harb Perspect Med       Date:  2012-07       Impact factor: 6.915

8.  A double point mutation in PCL-gamma1 (Y509A/F510A) enhances Y783 phosphorylation and inositol phospholipid-hydrolyzing activity upon EGF stimulation.

Authors:  Sang Hee Chung; Sung Kuk Kim; Jung Kuk Kim; Yong Ryoul Yang; Pann Ghill Suh; Jong Soo Chang
Journal:  Exp Mol Med       Date:  2010-03-31       Impact factor: 8.718

9.  A Peptide Uncoupling BDNF Receptor TrkB from Phospholipase Cγ1 Prevents Epilepsy Induced by Status Epilepticus.

Authors:  Bin Gu; Yang Zhong Huang; Xiao-Ping He; Rasesh B Joshi; Wonjo Jang; James O McNamara
Journal:  Neuron       Date:  2015-10-17       Impact factor: 17.173

10.  Phospholipase Cγ1 is required for pre-TCR signal transduction and pre-T cell development.

Authors:  Guoping Fu; Mei Yu; Yuhong Chen; Yongwei Zheng; Wen Zhu; Debra K Newman; Demin Wang; Renren Wen
Journal:  Eur J Immunol       Date:  2016-11-07       Impact factor: 5.532
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.