RNA structures and folding: from conventional to new issues in structure predictions.

Prediction and modeling of RNA structures has become an indispensable tool of biological research disciplines. Currently, reliable predictions require massive input of experimental data. Structure-forming elements are conventional base pairs, as well as a rapidly increasing repertoire of novel structural motifs. New developments extend structural analysis beyond the one-sequence/one-structure paradigm and allow questions that are relevant to molecular evolution to be answered.