Literature DB >> 9094328

Structure and dynamics of molecular motors.

L A Amos1, R A Cross.   

Abstract

The structures of the oppositely directed microtubule motors kinesin and ncd have been solved to atomic resolution. The two structures are very similar and are also homologous to myosin. Myosins and kinesins differ kinetically but, tantalizingly, cryoelectron microscopy has recently revealed that both structures may tilt during ADP release. Such evidence suggests that the two motor families use common structural mechanisms.

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Year:  1997        PMID: 9094328     DOI: 10.1016/s0959-440x(97)80032-2

Source DB:  PubMed          Journal:  Curr Opin Struct Biol        ISSN: 0959-440X            Impact factor:   6.809


  5 in total

1.  A molecular model for RecA-promoted strand exchange via parallel triple-stranded helices.

Authors:  G Bertucat; R Lavery; C Prévost
Journal:  Biophys J       Date:  1999-09       Impact factor: 4.033

2.  Nonlinear relaxation dynamics in elastic networks and design principles of molecular machines.

Authors:  Yuichi Togashi; Alexander S Mikhailov
Journal:  Proc Natl Acad Sci U S A       Date:  2007-05-16       Impact factor: 11.205

Review 3.  Invertebrate muscles: thin and thick filament structure; molecular basis of contraction and its regulation, catch and asynchronous muscle.

Authors:  Scott L Hooper; Kevin H Hobbs; Jeffrey B Thuma
Journal:  Prog Neurobiol       Date:  2008-06-20       Impact factor: 11.685

4.  Computational fragment-based drug design to explore the hydrophobic sub-pocket of the mitotic kinesin Eg5 allosteric binding site.

Authors:  Ksenia Oguievetskaia; Laetitia Martin-Chanas; Artem Vorotyntsev; Olivia Doppelt-Azeroual; Xavier Brotel; Stewart A Adcock; Alexandre G de Brevern; Francois Delfaud; Fabrice Moriaud
Journal:  J Comput Aided Mol Des       Date:  2009-06-17       Impact factor: 3.686

5.  Proteolytic mapping of kinesin/ncd-microtubule interface: nucleotide-dependent conformational changes in the loops L8 and L12.

Authors:  M C Alonso; J van Damme; J Vandekerckhove; R A Cross
Journal:  EMBO J       Date:  1998-02-16       Impact factor: 11.598

  5 in total

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