Inflammatory pseudotumor of epididymis and Epstein-Barr virus: a study of two cases.

Inflammatory pseudotumor (IP) is an uncommon tumor-like lesion of unknown etiology. Two cases of IP of the epididymis were identified in our hospital file. Having read a recent report on finding Epstein-Barr virus (EBV) in some cases of IP in lymph node, spleen and liver, the two cases of epididymal IP were tested for EBV-encoded small nuclear RNA 1 and 2 by in-situ hybridization. The absence of EBV RNA suggests that IP of epididymis may be etiologically distinct from that occurring in the organs of the reticuloendothelial system.