W Soldan1, J Henker, C Sprössig. 1. Department of Pediatrics, University of Technology, Dresden, Germany.
Abstract
BACKGROUND: The secretin-pancreozymin test has been accepted as the gold standard for testing exocrine pancreatic function. However, this test is invasive, time-consuming, and expensive. Therefore, in daily practice, more simple, indirect methods are proposed. METHODS: The fecal concentration of human pancreatic elastase (E1) has been assessed for diagnostic sensitivity and specificity. For sensitivity, fecal E1 determination in 23 healthy children were studied. RESULTS: Sensitivity to detect pancreatic insufficiency was 100% and specificity 96%. CONCLUSIONS: Fecal E1 concentration appears to be a more sensitive and specific test of pancreatic function than other tests.
BACKGROUND: The secretin-pancreozymin test has been accepted as the gold standard for testing exocrine pancreatic function. However, this test is invasive, time-consuming, and expensive. Therefore, in daily practice, more simple, indirect methods are proposed. METHODS: The fecal concentration of humanpancreatic elastase (E1) has been assessed for diagnostic sensitivity and specificity. For sensitivity, fecal E1 determination in 23 healthy children were studied. RESULTS: Sensitivity to detect pancreatic insufficiency was 100% and specificity 96%. CONCLUSIONS: Fecal E1 concentration appears to be a more sensitive and specific test of pancreatic function than other tests.
Authors: A Carroccio; F Verghi; B Santini; V Lucidi; G Iacono; F Cavataio; M Soresi; N Ansaldi; M Castro; G Montalto Journal: Dig Dis Sci Date: 2001-06 Impact factor: 3.199