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Literature DB >> 9093798

Correlation of interleukin-6 serum levels with bone density in postmenopausal women.

N G Papadopoulos¹, K Georganas, V Skoutellas, E Konstantellos, G P Lyritis.

Abstract

In order to identify possible correlations between interleukin-6 (IL-6) and hormonal and biochemical parameters of bone metabolism, or bone density, 24 postmenopausal women were studied. Serum IL-6, estradiol, calcium, phosphorus, osteocalcin, alkaline phosphatase, the urinary secretion of calcium, phosphorus and hydroxyproline, and bone density of the lumbar spine, femur and radius were measured. No significant correlation was found between IL-6 and the biochemical parameters. A negative correlation was found between IL-6 and serum estradiol, as well as between IL-6 and bone density in 5 out of 6 sites studied. It is possible that women with high IL-6 levels, may develop lower bone mass.

Entities: Chemical Gene Species

Mesh：

Substances：
Biomarkers
Interleukin-6

Year: 1997 PMID： 9093798 DOI： 10.1007/bf02247845

Source DB: PubMed Journal: Clin Rheumatol ISSN： 0770-3198 Impact factor: 2.980

16 in total

Review 1. The biology of interleukin-6.

Authors: T Kishimoto
Journal: Blood Date: 1989-07 Impact factor: 22.113

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Authors: N G Papadopoulos; G V Dedoussis; C N Baxevanis; M Papamichail
Journal: J Clin Lab Anal Date: 1995 Impact factor: 2.352

Review 3. Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis.

Authors: S C Manolagas; R L Jilka
Journal: N Engl J Med Date: 1995-02-02 Impact factor: 91.245

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Authors: R Bataille; M Jourdan; X G Zhang; B Klein
Journal: J Clin Invest Date: 1989-12 Impact factor: 14.808

5. Evidence for an autocrine/paracrine role for interleukin-6 in bone resorption by giant cells from giant cell tumors of bone.

Authors: Y Ohsaki; S Takahashi; T Scarcez; A Demulder; T Nishihara; R Williams; G D Roodman
Journal: Endocrinology Date: 1992-11 Impact factor: 4.736

6. Cytokine production by peripheral blood cells in postmenopausal osteoporosis.

Authors: M T Zarrabeitia; J A Riancho; J A Amado; J Napal; J Gonzalez-Macias
Journal: Bone Miner Date: 1991-08

7. Biochemical markers of bone turnover for the clinical assessment of bone metabolism.

Authors: A K Taylor; S A Lueken; C Libanati; D J Baylink
Journal: Rheum Dis Clin North Am Date: 1994-08 Impact factor: 2.670

8. Circulating cytokine levels in osteoporotic and normal women.

Authors: S Khosla; J M Peterson; K Egan; J D Jones; B L Riggs
Journal: J Clin Endocrinol Metab Date: 1994-09 Impact factor: 5.958

9. Elevated plasma levels of interleukin-6 in postmenopausal women do not correlate with bone density.

Authors: D M Kania; N Binkley; M Checovich; T Havighurst; M Schilling; W B Ershler
Journal: J Am Geriatr Soc Date: 1995-03 Impact factor: 5.562

Review 10. Bone cytokines.

Authors: M C de Vernejoul; M Cohen-Solal; P Orcel
Journal: Curr Opin Rheumatol Date: 1993-05 Impact factor: 5.006

8 in total

Correlation of interleukin-6 serum levels with bone density in postmenopausal women.

Review 1. The biology of interleukin-6.

2. Bioassay vs. immunoassay for quantification of interleukin-6 in biological fluids.

Review 3. Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis.

4. Serum levels of interleukin 6, a potent myeloma cell growth factor, as a reflect of disease severity in plasma cell dyscrasias.

5. Evidence for an autocrine/paracrine role for interleukin-6 in bone resorption by giant cells from giant cell tumors of bone.

6. Cytokine production by peripheral blood cells in postmenopausal osteoporosis.

7. Biochemical markers of bone turnover for the clinical assessment of bone metabolism.

8. Circulating cytokine levels in osteoporotic and normal women.

9. Elevated plasma levels of interleukin-6 in postmenopausal women do not correlate with bone density.

Review 10. Bone cytokines.

Review 1. The bone-adipose axis in obesity and weight loss.

Review 2. Proinflammatory cytokines and osteoporosis.

3. Suppression of bone resorption by madindoline A, a novel nonpeptide antagonist to gp130.

4. Endogenous estradiol and inflammation biomarkers: potential interacting mechanisms of obesity-related disease.

5. Association between inflammatory biomarkers and bone mineral density in a community-based cohort of men and women.

6. Ovariectomy Activates Chronic Low-Grade Inflammation Mediated by Memory T Cells, Which Promotes Osteoporosis in Mice.

7. Modifiable risk factors associated with bone deficits in childhood cancer survivors.

8. Inflammatory markers and bone health in postmenopausal women: a cross-sectional overview.