| Literature DB >> 9092473 |
L Guo1, K B Lim, J S Gunn, B Bainbridge, R P Darveau, M Hackett, S I Miller.
Abstract
Bacterial pathogenesis requires proteins that sense host microenvironments and respond by regulating virulence gene transcription. For Salmonellae, one such regulatory system is PhoP-PhoQ, which regulates genes required for intracellular survival and resistance to cationic peptides. Analysis by mass spectrometry revealed that Salmonella typhimurium PhoP-PhoQ regulated structural modifications of lipid A, the host signaling portion of lipopolysaccharide (LPS), by the addition of aminoarabinose and 2-hydroxymyristate. Structurally modified lipid A altered LPS-mediated expression of the adhesion molecule E-selectin by endothelial cells and tumor necrosis factor-alpha expression by adherent monocytes. Thus, altered responses to environmentally induced lipid A structural modifications may represent a mechanism for bacteria to gain advantage within host tissues.Entities:
Mesh：
Substances：
Year: 1997 PMID： 9092473 DOI： 10.1126/science.276.5310.250
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728